FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2511895913> ?p ?o ?g. }

• W2511895913 endingPage "90" @default.
• W2511895913 startingPage "82" @default.
• W2511895913 abstract "Intraventricular hemorrhage (IVH) is the most frequent, severe neurological complication of prematurity and is associated with posthemorrhagic hydrocephalus (PHH) in up to half of cases. PHH requires lifelong neurosurgical care and is associated with significant cognitive and psychomotor disability. Cerebrospinal fluid (CSF) biomarkers may provide both diagnostic information for PHH and novel insights into its pathophysiology.To explore the diagnostic ability of candidate CSF biomarkers for PHH.Concentrations of amyloid precursor protein (APP), soluble APPα (sAPPα), soluble APPβ, neural cell adhesion molecule-1 (NCAM-1), L1 cell adhesion molecule (L1CAM), tau, phosphorylated tau, and total protein (TP) were measured in lumbar CSF from neonates in 6 groups: (1) no known neurological disease (n = 33); (2) IVH grades I to II (n = 13); (3) IVH grades III to IV (n = 12); (4) PHH (n = 12); (5) ventricular enlargement without hydrocephalus (n = 10); and (6) hypoxic ischemic encephalopathy (n = 13). CSF protein levels were compared using analysis of variance, and logistic regression was performed to examine the predictive ability of each marker for PHH.Lumbar CSF levels of APP, sAPPα, L1CAM, and TP were selectively increased in PHH compared with all other conditions (all P < .001). The sensitivity, specificity, and odds ratios of candidate CSF biomarkers for PHH were determined for APP, sAPPα, and L1CAM; cut points of 699, 514, and 113 ng/mL yielded odds ratios for PHH of 80.0, 200.0, and 68.75, respectively.Lumbar CSF APP, sAPPα, L1CAM, and TP were selectively increased in PHH. These proteins, and sAPPα, in particular, hold promise as biomarkers of PHH and provide novel insight into PHH-associated neural injury and repair." @default.
• W2511895913 created "2016-09-16" @default.
• W2511895913 creator A5003782466 @default.
• W2511895913 creator A5034720790 @default.
• W2511895913 creator A5047902234 @default.
• W2511895913 creator A5051817529 @default.
• W2511895913 creator A5053569770 @default.
• W2511895913 creator A5057246360 @default.
• W2511895913 creator A5058555412 @default.
• W2511895913 creator A5077647622 @default.
• W2511895913 creator A5079141970 @default.
• W2511895913 creator A5088998527 @default.
• W2511895913 date "2016-08-26" @default.
• W2511895913 modified "2023-10-17" @default.
• W2511895913 title "Lumbar Cerebrospinal Fluid Biomarkers of Posthemorrhagic Hydrocephalus of Prematurity: Amyloid Precursor Protein, Soluble Amyloid Precursor Protein α, and L1 Cell Adhesion Molecule" @default.
• W2511895913 cites W1595656231 @default.
• W2511895913 cites W1700194686 @default.
• W2511895913 cites W180826610 @default.
• W2511895913 cites W1857797615 @default.
• W2511895913 cites W1965222181 @default.
• W2511895913 cites W1965839177 @default.
• W2511895913 cites W1971814147 @default.
• W2511895913 cites W1972468142 @default.
• W2511895913 cites W1973223945 @default.
• W2511895913 cites W1976645944 @default.
• W2511895913 cites W1980242255 @default.
• W2511895913 cites W1981615742 @default.
• W2511895913 cites W1983023206 @default.
• W2511895913 cites W1997551248 @default.
• W2511895913 cites W2001445086 @default.
• W2511895913 cites W2003955249 @default.
• W2511895913 cites W2004372993 @default.
• W2511895913 cites W2015115312 @default.
• W2511895913 cites W2018939969 @default.
• W2511895913 cites W2025030210 @default.
• W2511895913 cites W2026279664 @default.
• W2511895913 cites W2027683487 @default.
• W2511895913 cites W2041371814 @default.
• W2511895913 cites W2044018508 @default.
• W2511895913 cites W2044726013 @default.
• W2511895913 cites W2046189979 @default.
• W2511895913 cites W2046224781 @default.
• W2511895913 cites W2050447440 @default.
• W2511895913 cites W2055549832 @default.
• W2511895913 cites W2059992863 @default.
• W2511895913 cites W2065496524 @default.
• W2511895913 cites W2069350576 @default.
• W2511895913 cites W2075705981 @default.
• W2511895913 cites W2077247278 @default.
• W2511895913 cites W2079162969 @default.
• W2511895913 cites W2091048651 @default.
• W2511895913 cites W2091196687 @default.
• W2511895913 cites W2093733104 @default.
• W2511895913 cites W2111428621 @default.
• W2511895913 cites W2112836819 @default.
• W2511895913 cites W2117683711 @default.
• W2511895913 cites W2129085204 @default.
• W2511895913 cites W2129467154 @default.
• W2511895913 cites W2135158408 @default.
• W2511895913 cites W2138419746 @default.
• W2511895913 cites W2146215440 @default.
• W2511895913 cites W2150702063 @default.
• W2511895913 cites W2166601114 @default.
• W2511895913 cites W2332962656 @default.
• W2511895913 cites W4431115 @default.
• W2511895913 doi "https://doi.org/10.1227/neu.0000000000001415" @default.
• W2511895913 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5326702" @default.
• W2511895913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27571524" @default.
• W2511895913 hasPublicationYear "2016" @default.
• W2511895913 type Work @default.
• W2511895913 sameAs 2511895913 @default.
• W2511895913 citedByCount "22" @default.
• W2511895913 countsByYear W25118959132017 @default.
• W2511895913 countsByYear W25118959132018 @default.
• W2511895913 countsByYear W25118959132019 @default.
• W2511895913 countsByYear W25118959132020 @default.
• W2511895913 countsByYear W25118959132021 @default.
• W2511895913 countsByYear W25118959132022 @default.
• W2511895913 countsByYear W25118959132023 @default.
• W2511895913 crossrefType "journal-article" @default.
• W2511895913 hasAuthorship W2511895913A5003782466 @default.
• W2511895913 hasAuthorship W2511895913A5034720790 @default.
• W2511895913 hasAuthorship W2511895913A5047902234 @default.
• W2511895913 hasAuthorship W2511895913A5051817529 @default.
• W2511895913 hasAuthorship W2511895913A5053569770 @default.
• W2511895913 hasAuthorship W2511895913A5057246360 @default.
• W2511895913 hasAuthorship W2511895913A5058555412 @default.
• W2511895913 hasAuthorship W2511895913A5077647622 @default.
• W2511895913 hasAuthorship W2511895913A5079141970 @default.
• W2511895913 hasAuthorship W2511895913A5088998527 @default.
• W2511895913 hasBestOaLocation W25118959132 @default.
• W2511895913 hasConcept C126322002 @default.
• W2511895913 hasConcept C141071460 @default.
• W2511895913 hasConcept C142724271 @default.
• W2511895913 hasConcept C2778134817 @default.
• W2511895913 hasConcept C2779134260 @default.
• W2511895913 hasConcept C2779651940 @default.
• W2511895913 hasConcept C31705614 @default.

• next