Matches in SemOpenAlex for { <https://semopenalex.org/work/W2512071364> ?p ?o ?g. }
- W2512071364 endingPage "1260" @default.
- W2512071364 startingPage "1260" @default.
- W2512071364 abstract "Neuronal apoptosis is mediated by intrinsic and extrinsic signaling pathways such as the membrane-mediated, mitochondrial, and endoplasmic reticulum stress pathways. Few studies have examined the endoplasmic reticulum-mediated apoptosis pathway in the penumbra after traumatic brain injury, and it remains unclear whether endoplasmic reticulum stress can activate the caspase-12-dependent apoptotic pathway in the traumatic penumbra. Here, we established rat models of fluid percussion-induced traumatic brain injury and found that protein expression of caspase-12, caspase-3 and the endoplasmic reticulum stress marker 78 kDa glucose-regulated protein increased in the traumatic penumbra 6 hours after injury and peaked at 24 hours. Furthermore, numbers of terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling-positive cells in the traumatic penumbra also reached peak levels 24 hours after injury. These findings suggest that caspase-12-mediated endoplasmic reticulum-related apoptosis is activated in the traumatic penumbra, and may play an important role in the pathophysiology of secondary brain injury." @default.
- W2512071364 created "2016-09-16" @default.
- W2512071364 creator A5008261333 @default.
- W2512071364 creator A5037249009 @default.
- W2512071364 creator A5053107081 @default.
- W2512071364 creator A5073704425 @default.
- W2512071364 creator A5078612532 @default.
- W2512071364 creator A5082621414 @default.
- W2512071364 creator A5082965851 @default.
- W2512071364 date "2016-01-01" @default.
- W2512071364 modified "2023-10-12" @default.
- W2512071364 title "Endoplasmic reticulum stress-induced apoptosis in the penumbra aggravates secondary damage in rats with traumatic brain injury" @default.
- W2512071364 cites W1491493125 @default.
- W2512071364 cites W1502742746 @default.
- W2512071364 cites W1519487278 @default.
- W2512071364 cites W1862284587 @default.
- W2512071364 cites W1872112746 @default.
- W2512071364 cites W1905806846 @default.
- W2512071364 cites W1965995518 @default.
- W2512071364 cites W1966543941 @default.
- W2512071364 cites W1967242036 @default.
- W2512071364 cites W1970156056 @default.
- W2512071364 cites W1988019001 @default.
- W2512071364 cites W1990363097 @default.
- W2512071364 cites W1990514899 @default.
- W2512071364 cites W1992605674 @default.
- W2512071364 cites W2002439304 @default.
- W2512071364 cites W2003115198 @default.
- W2512071364 cites W2005866728 @default.
- W2512071364 cites W2031116054 @default.
- W2512071364 cites W2031213243 @default.
- W2512071364 cites W2034213169 @default.
- W2512071364 cites W2039228125 @default.
- W2512071364 cites W2044043514 @default.
- W2512071364 cites W2049923824 @default.
- W2512071364 cites W2064950130 @default.
- W2512071364 cites W2067159032 @default.
- W2512071364 cites W2078310745 @default.
- W2512071364 cites W2078500987 @default.
- W2512071364 cites W2079107172 @default.
- W2512071364 cites W2087847672 @default.
- W2512071364 cites W2107933397 @default.
- W2512071364 cites W2129985526 @default.
- W2512071364 cites W2144135883 @default.
- W2512071364 cites W2156180278 @default.
- W2512071364 cites W2192080449 @default.
- W2512071364 cites W2225872742 @default.
- W2512071364 cites W2288527496 @default.
- W2512071364 cites W2295946298 @default.
- W2512071364 cites W2297662019 @default.
- W2512071364 cites W2300981798 @default.
- W2512071364 cites W2336071846 @default.
- W2512071364 cites W2341291097 @default.
- W2512071364 cites W71320661 @default.
- W2512071364 cites W88644589 @default.
- W2512071364 doi "https://doi.org/10.4103/1673-5374.189190" @default.
- W2512071364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5020824" @default.
- W2512071364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27651773" @default.
- W2512071364 hasPublicationYear "2016" @default.
- W2512071364 type Work @default.
- W2512071364 sameAs 2512071364 @default.
- W2512071364 citedByCount "22" @default.
- W2512071364 countsByYear W25120713642017 @default.
- W2512071364 countsByYear W25120713642018 @default.
- W2512071364 countsByYear W25120713642019 @default.
- W2512071364 countsByYear W25120713642020 @default.
- W2512071364 countsByYear W25120713642022 @default.
- W2512071364 countsByYear W25120713642023 @default.
- W2512071364 crossrefType "journal-article" @default.
- W2512071364 hasAuthorship W2512071364A5008261333 @default.
- W2512071364 hasAuthorship W2512071364A5037249009 @default.
- W2512071364 hasAuthorship W2512071364A5053107081 @default.
- W2512071364 hasAuthorship W2512071364A5073704425 @default.
- W2512071364 hasAuthorship W2512071364A5078612532 @default.
- W2512071364 hasAuthorship W2512071364A5082621414 @default.
- W2512071364 hasAuthorship W2512071364A5082965851 @default.
- W2512071364 hasBestOaLocation W25120713641 @default.
- W2512071364 hasConcept C118552586 @default.
- W2512071364 hasConcept C126322002 @default.
- W2512071364 hasConcept C158617107 @default.
- W2512071364 hasConcept C190283241 @default.
- W2512071364 hasConcept C2780577055 @default.
- W2512071364 hasConcept C2781017439 @default.
- W2512071364 hasConcept C31573885 @default.
- W2512071364 hasConcept C541997718 @default.
- W2512071364 hasConcept C55493867 @default.
- W2512071364 hasConcept C71924100 @default.
- W2512071364 hasConcept C86803240 @default.
- W2512071364 hasConcept C95444343 @default.
- W2512071364 hasConcept C98424977 @default.
- W2512071364 hasConceptScore W2512071364C118552586 @default.
- W2512071364 hasConceptScore W2512071364C126322002 @default.
- W2512071364 hasConceptScore W2512071364C158617107 @default.
- W2512071364 hasConceptScore W2512071364C190283241 @default.
- W2512071364 hasConceptScore W2512071364C2780577055 @default.
- W2512071364 hasConceptScore W2512071364C2781017439 @default.
- W2512071364 hasConceptScore W2512071364C31573885 @default.
- W2512071364 hasConceptScore W2512071364C541997718 @default.