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- W2512144974 abstract "No vaccine exists against group A Streptococcus (GAS), a leading cause of worldwide morbidity and mortality. A severe hurdle is the hypervariability of its major antigen, the M protein, with >200 different M types known. Neutralizing antibodies typically recognize M protein hypervariable regions (HVRs) and confer narrow protection. In stark contrast, human C4b-binding protein (C4BP), which is recruited to the GAS surface to block phagocytic killing, interacts with a remarkably large number of M protein HVRs (apparently ∼90%). Such broad recognition is rare, and we discovered a unique mechanism for this through the structure determination of four sequence-diverse M proteins in complexes with C4BP. The structures revealed a uniform and tolerant ‘reading head’ in C4BP, which detected conserved sequence patterns hidden within hypervariability. Our results open up possibilities for rational therapies that target the M–C4BP interaction, and also inform a path towards vaccine design. Crystal structures of hypervariable group A Streptocococus M proteins define a conserved binding modality to complement the associated C4b-binding protein." @default.
- W2512144974 created "2016-09-16" @default.
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- W2512144974 date "2016-09-05" @default.
- W2512144974 modified "2023-10-16" @default.
- W2512144974 title "Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein" @default.
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- W2512144974 doi "https://doi.org/10.1038/nmicrobiol.2016.155" @default.
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