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- W2512156653 startingPage "e2389" @default.
- W2512156653 abstract "8-Hydroxyquinoline and derivatives exhibit multifunctional properties, including antioxidant, antineurodegenerative, anticancer, anti-inflammatory and antidiabetic activities. In biological systems, elevation of intracellular calcium can cause calpain activation, leading to cell death. Here, the effect of 8-hydroxyquinoline and derivatives (5-chloro-7-iodo-8-hydroxyquinoline or clioquinol and 8-hydroxy-5-nitroquinoline or nitroxoline) on calpain-dependent (calpain-calpastatin) pathways in human neuroblastoma (SH-SY5Y) cells was investigated. 8-Hydroxyquinoline and derivatives ameliorated high glucose toxicity in SH-SY5Y cells. The investigated compounds, particularly clioquinol, attenuated the increased expression of calpain, even under high-glucose conditions. 8-Hydroxyquinoline and derivatives thus adversely affected the promotion of neuronal cell death by high glucose via the calpain-calpastatin signaling pathways. These findings support the beneficial effects of 8-hydroxyquinolines for further therapeutic development." @default.
- W2512156653 created "2016-09-16" @default.
- W2512156653 creator A5020233251 @default.
- W2512156653 creator A5076619965 @default.
- W2512156653 creator A5078410504 @default.
- W2512156653 date "2016-08-31" @default.
- W2512156653 modified "2023-10-14" @default.
- W2512156653 title "Effect of 8-hydroxyquinoline and derivatives on human neuroblastoma SH-SY5Y cells under high glucose" @default.
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- W2512156653 doi "https://doi.org/10.7717/peerj.2389" @default.
- W2512156653 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5012261" @default.
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