FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2512217879> ?p ?o ?g. }

• W2512217879 endingPage "5109" @default.
• W2512217879 startingPage "5103" @default.
• W2512217879 abstract "Temozolomide is a chemotherapeutic agent that is used in the treatment of glioblastoma and other malignant gliomas. It acts through DNA alkylation, but treatment is limited by its systemic toxicity and neutralization of DNA alkylation by upregulation of the O6-methylguanine-DNA methyltransferase gene. Both of these limiting factors can be addressed by achieving higher concentrations of TMZ in the brain. Our research has led to the discovery of new analogs of temozolomide with improved brain:plasma ratios when dosed in vivo in rats. These compounds are imidazotetrazine analogs, expected to act through the same mechanism as temozolomide. With reduced systemic exposure, these new agents have the potential to improve efficacy and therapeutic index in the treatment of glioblastoma." @default.
• W2512217879 created "2016-09-16" @default.
• W2512217879 creator A5008209525 @default.
• W2512217879 creator A5019825677 @default.
• W2512217879 creator A5019847000 @default.
• W2512217879 creator A5026882185 @default.
• W2512217879 creator A5030328435 @default.
• W2512217879 creator A5031226563 @default.
• W2512217879 creator A5032788653 @default.
• W2512217879 creator A5041762835 @default.
• W2512217879 creator A5049235424 @default.
• W2512217879 creator A5056413943 @default.
• W2512217879 creator A5056619917 @default.
• W2512217879 creator A5063015158 @default.
• W2512217879 creator A5065711515 @default.
• W2512217879 creator A5067255118 @default.
• W2512217879 creator A5069600231 @default.
• W2512217879 creator A5071358816 @default.
• W2512217879 creator A5072565818 @default.
• W2512217879 creator A5074907447 @default.
• W2512217879 creator A5077814448 @default.
• W2512217879 creator A5078030039 @default.
• W2512217879 creator A5083864541 @default.
• W2512217879 creator A5086013887 @default.
• W2512217879 creator A5091752977 @default.
• W2512217879 date "2016-10-01" @default.
• W2512217879 modified "2023-09-26" @default.
• W2512217879 title "Temozolomide analogs with improved brain/plasma ratios – Exploring the possibility of enhancing the therapeutic index of temozolomide" @default.
• W2512217879 cites W1971513938 @default.
• W2512217879 cites W1972359014 @default.
• W2512217879 cites W2007861368 @default.
• W2512217879 cites W2011592536 @default.
• W2512217879 cites W2011873911 @default.
• W2512217879 cites W2066686182 @default.
• W2512217879 cites W2073908502 @default.
• W2512217879 cites W2135423880 @default.
• W2512217879 cites W2135462171 @default.
• W2512217879 cites W2146107023 @default.
• W2512217879 cites W2148276738 @default.
• W2512217879 cites W2154451644 @default.
• W2512217879 cites W2158649478 @default.
• W2512217879 cites W2167713837 @default.
• W2512217879 cites W2321980425 @default.
• W2512217879 doi "https://doi.org/10.1016/j.bmcl.2016.08.064" @default.
• W2512217879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27614414" @default.
• W2512217879 hasPublicationYear "2016" @default.
• W2512217879 type Work @default.
• W2512217879 sameAs 2512217879 @default.
• W2512217879 citedByCount "12" @default.
• W2512217879 countsByYear W25122178792018 @default.
• W2512217879 countsByYear W25122178792020 @default.
• W2512217879 countsByYear W25122178792021 @default.
• W2512217879 countsByYear W25122178792022 @default.
• W2512217879 countsByYear W25122178792023 @default.
• W2512217879 crossrefType "journal-article" @default.
• W2512217879 hasAuthorship W2512217879A5008209525 @default.
• W2512217879 hasAuthorship W2512217879A5019825677 @default.
• W2512217879 hasAuthorship W2512217879A5019847000 @default.
• W2512217879 hasAuthorship W2512217879A5026882185 @default.
• W2512217879 hasAuthorship W2512217879A5030328435 @default.
• W2512217879 hasAuthorship W2512217879A5031226563 @default.
• W2512217879 hasAuthorship W2512217879A5032788653 @default.
• W2512217879 hasAuthorship W2512217879A5041762835 @default.
• W2512217879 hasAuthorship W2512217879A5049235424 @default.
• W2512217879 hasAuthorship W2512217879A5056413943 @default.
• W2512217879 hasAuthorship W2512217879A5056619917 @default.
• W2512217879 hasAuthorship W2512217879A5063015158 @default.
• W2512217879 hasAuthorship W2512217879A5065711515 @default.
• W2512217879 hasAuthorship W2512217879A5067255118 @default.
• W2512217879 hasAuthorship W2512217879A5069600231 @default.
• W2512217879 hasAuthorship W2512217879A5071358816 @default.
• W2512217879 hasAuthorship W2512217879A5072565818 @default.
• W2512217879 hasAuthorship W2512217879A5074907447 @default.
• W2512217879 hasAuthorship W2512217879A5077814448 @default.
• W2512217879 hasAuthorship W2512217879A5078030039 @default.
• W2512217879 hasAuthorship W2512217879A5083864541 @default.
• W2512217879 hasAuthorship W2512217879A5086013887 @default.
• W2512217879 hasAuthorship W2512217879A5091752977 @default.
• W2512217879 hasConcept C104317684 @default.
• W2512217879 hasConcept C126322002 @default.
• W2512217879 hasConcept C127561419 @default.
• W2512217879 hasConcept C142724271 @default.
• W2512217879 hasConcept C150903083 @default.
• W2512217879 hasConcept C185592680 @default.
• W2512217879 hasConcept C19831878 @default.
• W2512217879 hasConcept C207001950 @default.
• W2512217879 hasConcept C2776194525 @default.
• W2512217879 hasConcept C2776694085 @default.
• W2512217879 hasConcept C2777389519 @default.
• W2512217879 hasConcept C2779130545 @default.
• W2512217879 hasConcept C2779527866 @default.
• W2512217879 hasConcept C2780035454 @default.
• W2512217879 hasConcept C33288867 @default.
• W2512217879 hasConcept C502942594 @default.
• W2512217879 hasConcept C552990157 @default.
• W2512217879 hasConcept C55493867 @default.
• W2512217879 hasConcept C71924100 @default.
• W2512217879 hasConcept C86803240 @default.

• next