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- W2512372941 abstract "CYLD is a deubiquitinating enzyme that exerts a tumor suppressive function. Its downregulation or inactivation has been associated with the development of several types of malignancies including hepatocellular carcinoma (HCC). HCC cells display significantly lower Cyld expression compared to primary human hepatocytes, and Cyld downregulation can contribute to apoptotic resistance of HCC cells. Little is known about the mechanism of Cyld downregulation in human HCC cells. In the present study we explored the possible regulation of Cyld expression by histone deacetylases (HDACs) in human HCC cell lines. We demonstrated that the HDAC inhibitors suberoylanilide hydroxamic acid, sodium butyrate, and trichostatin A induced the upregulation of both mRNA and protein levels of CYLD in two different HCC cell lines, HepG2 and Huh7. Our results demonstrate the involvement of HDACs in the downregulation of Cyld expression in HCC cells and support and may improve the use of HDAC inhibitors for the treatment for HCC." @default.
- W2512372941 created "2016-09-16" @default.
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- W2512372941 date "2016-08-29" @default.
- W2512372941 modified "2023-10-16" @default.
- W2512372941 title "The expression of tumor suppressor geneCyldis upregulated by histone deacetylace inhibitors in human hepatocellular carcinoma cell lines" @default.
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- W2512372941 doi "https://doi.org/10.1002/cbf.3212" @default.
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