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- W2512401462 abstract "Summary. The severity of interstitial infl ammation and fi brosis are the most important prognostic criteria of renal response to chemotherapy in myeloma nephropathy. Urinary excretion of proinfl ammatory and profi brogenic mediators NF-kB, MCP-1, TGF-beta1 were studied in patients with multiple myeloma (MM) with severe renal failure to evaluate their signifi cance for the diagnosis of renal involvement severity and reversibility. The absence of renal response was associated with higher urinary excretion of NF-kB before therapy; this could indicate a more severe interstitial involvement. Urinary excretion of NF-kB in MM with renal failure (RF) changed over the course of therapy, depending on the renal response. This seemed to be caused by stimulation of various NF-kB subtypes during diff erent periods of interstitial infl ammation in the kidneys. Normalization of MCP-1 and TGF-beta was recorded only in the patients with complete hematological response, which indicated that the cytokine damage to the renal interstitium was arrested. Moreover, renal function more often improved in the patients with complete remission attained than in those with less complete hematological response. These data confi rmed that complete hematological remission should be the fi nal goal in MM with severe RF.Key words: myeloma nephropathy, cytokines, interstitial fi brosis, multiple myeloma" @default.
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- W2512401462 date "2012-01-01" @default.
- W2512401462 modified "2023-09-26" @default.
- W2512401462 title "THE ROLE OF PROINFLAMMATORY AND PROFIBROGENIC MEDIATORS IN THE PATHOGENESIS OF RENAL INVOLVEMENT IN MULTIPLE MYELOMA" @default.
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