Matches in SemOpenAlex for { <https://semopenalex.org/work/W2512468347> ?p ?o ?g. }
- W2512468347 endingPage "58" @default.
- W2512468347 startingPage "50" @default.
- W2512468347 abstract "Although best known as a selective estrogen receptor modulator (SERM), tamoxifen is a drug with a wide range of activities. Tamoxifen has demonstrated some efficacy has a therapeutic for bipolar mania and is believed to exert these effects through inhibition of protein kinase C (PKC). As the symptoms of amphetamine treatment in rodents are believed to mimic the symptoms of a manic episode, many of the preclinical studies for this indication have demonstrated that tamoxifen inhibits amphetamine action. The amphetamine-induced increase in extracellular dopamine which gives rise to the ‘manic’ effects is due to interaction of amphetamine with the dopamine transporter. We and others have demonstrated that PKC reduces amphetamine-induced reverse transport through the dopamine transporter. In this review, we will outline the actions of tamoxifen as a SERM and further detail another known action of tamoxifen—inhibition of PKC. We will summarize the literature showing how tamoxifen affects amphetamine action. Finally, we will present our hypothesis that tamoxifen, or an analog, could be used therapeutically to reduce amphetamine abuse in addition to treating mania." @default.
- W2512468347 created "2016-09-16" @default.
- W2512468347 creator A5002950613 @default.
- W2512468347 creator A5044999083 @default.
- W2512468347 creator A5082669025 @default.
- W2512468347 date "2017-10-01" @default.
- W2512468347 modified "2023-10-02" @default.
- W2512468347 title "Tamoxifen and amphetamine abuse: Are there therapeutic possibilities?" @default.
- W2512468347 cites W112387632 @default.
- W2512468347 cites W1483496794 @default.
- W2512468347 cites W1509103176 @default.
- W2512468347 cites W1513285718 @default.
- W2512468347 cites W1525133179 @default.
- W2512468347 cites W1572088760 @default.
- W2512468347 cites W1848737477 @default.
- W2512468347 cites W1880119091 @default.
- W2512468347 cites W1892675218 @default.
- W2512468347 cites W1917367513 @default.
- W2512468347 cites W1922999816 @default.
- W2512468347 cites W1935820490 @default.
- W2512468347 cites W1954660866 @default.
- W2512468347 cites W1964892539 @default.
- W2512468347 cites W1965345502 @default.
- W2512468347 cites W1967521605 @default.
- W2512468347 cites W1967848367 @default.
- W2512468347 cites W1972336815 @default.
- W2512468347 cites W1972943445 @default.
- W2512468347 cites W1973196884 @default.
- W2512468347 cites W1974997673 @default.
- W2512468347 cites W1975809719 @default.
- W2512468347 cites W1975941800 @default.
- W2512468347 cites W1976336530 @default.
- W2512468347 cites W1977687298 @default.
- W2512468347 cites W1977982149 @default.
- W2512468347 cites W1980371813 @default.
- W2512468347 cites W1980701895 @default.
- W2512468347 cites W1982244071 @default.
- W2512468347 cites W1982518867 @default.
- W2512468347 cites W1982544366 @default.
- W2512468347 cites W1983392920 @default.
- W2512468347 cites W1986475800 @default.
- W2512468347 cites W1986685858 @default.
- W2512468347 cites W1989052524 @default.
- W2512468347 cites W1989275190 @default.
- W2512468347 cites W1992840778 @default.
- W2512468347 cites W1997802338 @default.
- W2512468347 cites W2004866911 @default.
- W2512468347 cites W2005060284 @default.
- W2512468347 cites W2006025698 @default.
- W2512468347 cites W2008376161 @default.
- W2512468347 cites W2009237276 @default.
- W2512468347 cites W2010539749 @default.
- W2512468347 cites W2011745000 @default.
- W2512468347 cites W201704258 @default.
- W2512468347 cites W2017723148 @default.
- W2512468347 cites W2019268044 @default.
- W2512468347 cites W2019626637 @default.
- W2512468347 cites W2020414527 @default.
- W2512468347 cites W2020903493 @default.
- W2512468347 cites W2021153026 @default.
- W2512468347 cites W2022094938 @default.
- W2512468347 cites W2023765433 @default.
- W2512468347 cites W2024050959 @default.
- W2512468347 cites W2025956185 @default.
- W2512468347 cites W2028438608 @default.
- W2512468347 cites W2029585121 @default.
- W2512468347 cites W2031647610 @default.
- W2512468347 cites W2032469368 @default.
- W2512468347 cites W2033347903 @default.
- W2512468347 cites W2035499822 @default.
- W2512468347 cites W2036342544 @default.
- W2512468347 cites W2038071695 @default.
- W2512468347 cites W2041209116 @default.
- W2512468347 cites W2042424580 @default.
- W2512468347 cites W2044600697 @default.
- W2512468347 cites W2044702943 @default.
- W2512468347 cites W2045100800 @default.
- W2512468347 cites W2051262966 @default.
- W2512468347 cites W2059248417 @default.
- W2512468347 cites W2060661891 @default.
- W2512468347 cites W2060897125 @default.
- W2512468347 cites W2060937634 @default.
- W2512468347 cites W2061563075 @default.
- W2512468347 cites W2062981323 @default.
- W2512468347 cites W2063009236 @default.
- W2512468347 cites W2063036662 @default.
- W2512468347 cites W2065197352 @default.
- W2512468347 cites W2065909153 @default.
- W2512468347 cites W2068819681 @default.
- W2512468347 cites W2070894000 @default.
- W2512468347 cites W2074002103 @default.
- W2512468347 cites W2078577857 @default.
- W2512468347 cites W2081529027 @default.
- W2512468347 cites W2083973655 @default.
- W2512468347 cites W2086383194 @default.
- W2512468347 cites W2087288531 @default.
- W2512468347 cites W2087932044 @default.
- W2512468347 cites W2090664057 @default.