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- W2512476656 abstract "Longitudinally extensive myelopathy (LEM) is a rare spinal syndrome, and was mostly assessed in western populations. In order to investigate the etiological, clinical, and radiological features of LEM in Chinese patients, we retrospectively analyzed eighty-nine (40 men and 49 women, median age 45.9 ± 15.7 years) patients with LEM hospitalized in China-Japan Friendship Hospital. LEM comprised autoimmune inflammatory myelitis (n = 53), metabolic and compressive disorders (n = 13), vascular diseases (n = 10), neoplastic diseases (n = 7), infectious diseases (n = 4), and syringomyelia (n = 2). Neuromyelitis optica spectrum disorders (NMOSD) was the most common cause of transverse myelopathy identified in LEM (38/89 [42.7%]) characterized by intractable vomiting and hiccups and painful tonic spasms. Subacute combined degeneration and anterior spinal artery syndrome accounted for the largest non-transverse LEM, which selectively affected the spinal dorsal and/or lateral columns and the spinal anterior region, respectively. Radicular pain was common in anterior spinal artery syndrome. Postrema (n = 15, 39.5%) and cervical (n = 31, 81.6%) lesions were significantly increased in NMOSD versus non-NMOSD (n = 7, 13.7% and n = 34, 66.7%, respectively, p < 0.05]. Axial T2-weighted MRI indicated that 46 (51.7%) patients exhibited complete lesions; 43 (48.3%) patients exhibited non-transverse lesions, mainly unilateral or symmetrical tract lesions. Twenty-four (51.1%) LEM patients exhibited distinct gadolinium contrast enhancement. In this Chinese cohort, LEM was primarily attributed to NMOSD. While the etiological distribution in the non-NMOSD group was different from western populations, clinical and imaging features may facilitate a differential diagnosis." @default.
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- W2512476656 date "2016-10-01" @default.
- W2512476656 modified "2023-09-23" @default.
- W2512476656 title "Etiological, clinical, and radiological features of longitudinally extensive myelopathy in Chinese patients" @default.
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- W2512476656 doi "https://doi.org/10.1016/j.jocn.2015.12.048" @default.
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