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- W2512478956 abstract "Oxidative stress is associated with the pathology of neurodegenerative diseases. Identification of small molecules capable of protecting against oxidative stress is therefore of significant importance. In this context, a library of 76 hydroxy flavones, methoxy flavones and their 4-thio analogues has been evaluated for neuroprotection against H2O2-induced oxidative stress. This revealed the synthetic 7,8-dihydroxy 4-thioflavones as neuroprotective compounds, with 14d and 18d showing highest neuroprotective effects at lower concentrations (0.3 μM). Neuroprotection was found to be mediated via activation of the anti-apoptotic cell survival proteins of the ERK1/2 and PI3K/Akt pathways. Structure–activity relationship analysis revealed the B-ring phenyl group as essential for greater neuroprotection. Replacing the 4-CO moiety with a 4-CS moiety also generally enhanced neuroprotection." @default.
- W2512478956 created "2016-09-16" @default.
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- W2512478956 date "2016-11-01" @default.
- W2512478956 modified "2023-10-14" @default.
- W2512478956 title "Thioflavones as novel neuroprotective agents" @default.
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- W2512478956 doi "https://doi.org/10.1016/j.bmc.2016.09.006" @default.
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