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- W2512541206 abstract "Cowden syndrome is a rare, multisystem disease manifesting with increased hamartomas and neoplasms. Though meningioma has been documented in patients with Cowden syndrome, the relationship between these two phenomena is still unclear.We report a case of a 43-year-old female patient with a known PTEN mutation and clinical history of Cowden syndrome. A workup of headache demonstrated two skull base meningiomas. At the time of surgery, several additional tiny meningiomas were detected in the same region.The development of multiple meningiomas in a patient with predisposition for tumor is more than coincidental. Though PTEN mutations and deletions have not been shown to be critical for meningioma development, this case challenges that conclusion. In light of recent genetic advances in meningioma molecular pathogenesis, the role of the PTEN/AKT/PI3K pathway is discussed." @default.
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- W2512541206 date "2016-08-24" @default.
- W2512541206 modified "2023-09-26" @default.
- W2512541206 title "Multiple Meningiomas in a Patient with Cowden Syndrome" @default.
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- W2512541206 doi "https://doi.org/10.1055/s-0036-1584265" @default.
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