Matches in SemOpenAlex for { <https://semopenalex.org/work/W2512551752> ?p ?o ?g. }
- W2512551752 endingPage "301" @default.
- W2512551752 startingPage "292" @default.
- W2512551752 abstract "Iodide has direct effects on thyroid function. Several iodinated lipids are biosynthesized by the thyroid and they were postulated as intermediaries in the action of iodide. Among them, 2-iodohexadecanal (2-IHDA) has been identified and proposed to play a role in thyroid autoregulation. The aim of this study was to compare the effect of iodide and 2-IHDA on thyroid cell physiology. For this purpose, FRTL-5 thyroid cells were incubated with the two compounds during 24 or 48 h and several thyroid parameters were evaluated such as: iodide uptake, intracellular calcium and H2O2 levels. To further explore the molecular mechanism involved in 2-IHDA action, transcript and protein levels of genes involved in thyroid hormone biosynthesis, as well as the transcriptional expression of these genes were evaluated in the presence of iodide and 2-IHDA. The results obtained indicate that 2-IHDA reproduces the action of excess iodide on the Wolff-Chaikoff effect as well as on thyroid specific genes transcription supporting its role in thyroid autoregulation." @default.
- W2512551752 created "2016-09-16" @default.
- W2512551752 creator A5002412793 @default.
- W2512551752 creator A5014996520 @default.
- W2512551752 creator A5018335397 @default.
- W2512551752 creator A5021766853 @default.
- W2512551752 creator A5033318579 @default.
- W2512551752 creator A5033802198 @default.
- W2512551752 creator A5047005281 @default.
- W2512551752 creator A5047122876 @default.
- W2512551752 creator A5066447696 @default.
- W2512551752 creator A5084830705 @default.
- W2512551752 date "2016-12-01" @default.
- W2512551752 modified "2023-10-08" @default.
- W2512551752 title "Effects of 2-iodohexadecanal in the physiology of thyroid cells" @default.
- W2512551752 cites W1483628018 @default.
- W2512551752 cites W1566442244 @default.
- W2512551752 cites W1583392323 @default.
- W2512551752 cites W1819609506 @default.
- W2512551752 cites W1966074333 @default.
- W2512551752 cites W1969441806 @default.
- W2512551752 cites W1973705049 @default.
- W2512551752 cites W1973906535 @default.
- W2512551752 cites W1975150854 @default.
- W2512551752 cites W1975958399 @default.
- W2512551752 cites W1983627886 @default.
- W2512551752 cites W1985074815 @default.
- W2512551752 cites W1987083838 @default.
- W2512551752 cites W1989682006 @default.
- W2512551752 cites W1990785639 @default.
- W2512551752 cites W1991535468 @default.
- W2512551752 cites W1994095687 @default.
- W2512551752 cites W1995177037 @default.
- W2512551752 cites W2000876198 @default.
- W2512551752 cites W2002518487 @default.
- W2512551752 cites W2003402881 @default.
- W2512551752 cites W2004465685 @default.
- W2512551752 cites W2013425246 @default.
- W2512551752 cites W2014406863 @default.
- W2512551752 cites W2014571061 @default.
- W2512551752 cites W2025649458 @default.
- W2512551752 cites W2034818483 @default.
- W2512551752 cites W2039205571 @default.
- W2512551752 cites W2039948070 @default.
- W2512551752 cites W2040454971 @default.
- W2512551752 cites W2040784063 @default.
- W2512551752 cites W2043503174 @default.
- W2512551752 cites W2052639583 @default.
- W2512551752 cites W2053244541 @default.
- W2512551752 cites W2054210029 @default.
- W2512551752 cites W2058287432 @default.
- W2512551752 cites W2058494751 @default.
- W2512551752 cites W2059269212 @default.
- W2512551752 cites W2067318229 @default.
- W2512551752 cites W2072506800 @default.
- W2512551752 cites W2077692911 @default.
- W2512551752 cites W2086992325 @default.
- W2512551752 cites W2094949576 @default.
- W2512551752 cites W2105168909 @default.
- W2512551752 cites W2108305483 @default.
- W2512551752 cites W2113981126 @default.
- W2512551752 cites W2126554226 @default.
- W2512551752 cites W2132270568 @default.
- W2512551752 cites W2140434958 @default.
- W2512551752 cites W2144272606 @default.
- W2512551752 cites W2144849411 @default.
- W2512551752 cites W2147257839 @default.
- W2512551752 cites W2149603102 @default.
- W2512551752 cites W2158364676 @default.
- W2512551752 cites W2159421324 @default.
- W2512551752 cites W2163768946 @default.
- W2512551752 cites W2168805124 @default.
- W2512551752 cites W2170825678 @default.
- W2512551752 cites W2258288450 @default.
- W2512551752 cites W2266052209 @default.
- W2512551752 cites W2327543792 @default.
- W2512551752 cites W4211033417 @default.
- W2512551752 doi "https://doi.org/10.1016/j.mce.2016.08.036" @default.
- W2512551752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27568464" @default.
- W2512551752 hasPublicationYear "2016" @default.
- W2512551752 type Work @default.
- W2512551752 sameAs 2512551752 @default.
- W2512551752 citedByCount "17" @default.
- W2512551752 countsByYear W25125517522017 @default.
- W2512551752 countsByYear W25125517522018 @default.
- W2512551752 countsByYear W25125517522019 @default.
- W2512551752 countsByYear W25125517522020 @default.
- W2512551752 countsByYear W25125517522021 @default.
- W2512551752 countsByYear W25125517522022 @default.
- W2512551752 crossrefType "journal-article" @default.
- W2512551752 hasAuthorship W2512551752A5002412793 @default.
- W2512551752 hasAuthorship W2512551752A5014996520 @default.
- W2512551752 hasAuthorship W2512551752A5018335397 @default.
- W2512551752 hasAuthorship W2512551752A5021766853 @default.
- W2512551752 hasAuthorship W2512551752A5033318579 @default.
- W2512551752 hasAuthorship W2512551752A5033802198 @default.
- W2512551752 hasAuthorship W2512551752A5047005281 @default.
- W2512551752 hasAuthorship W2512551752A5047122876 @default.