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• W2512558375 abstract "Gastrointestinal vascular malformations are responsible for 2–8% of all cases of bleeding and 30–40% of all obscure hemorrhages, being the most frequent cause of occult bleeding in older people. The aim of this review was to provide an up-to-date report about the use of octreotide in bleeding from both hereditary and acquired vascular malformations of the gastrointestinal tract. A systematic literature search was performed, using the keywords “gastrointestinal vascular malformation”, “octreotide”, “angiodysplasia”, “portal hypertensive gastropathy”, “gastric antral vascular ectasia”, and “hereditary vascular malformations”. The first line therapy of acute/chronic bleeding from digestive vascular malformations is endoscopy, followed by angiographic embolization and surgical resection when this is unsuccessful. In the setting of difficult-to-treat patients, octreotide has been proposed as an alternative therapeutic strategy. Studies reported in the literature show a high efficacy and safety of octreotide, but described only a small number of enrolled patients, heterogeneous therapeutic schedules and short-term follow-up, with the exception of acute bleeding from esophageal varices. As a consequence, the use of octreotide is not approved in this setting and it is currently still prescribed as an off-label drug. Studies in larger populations are needed to confirm the promising results observed in the small case series reports, so as to provide physicians with a treatment option for patients without available alternatives. Octreotide could also determine a strong decrease in the management costs of these clinical conditions, and especially, could dramatically reduce hospital admission costs." @default.
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• W2512558375 date "2016-09-01" @default.
• W2512558375 modified "2023-10-16" @default.
• W2512558375 title "Gastrointestinal bleeding from vascular malformations: Is octreotide effective to rescue difficult-to-treat patients?" @default.
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• W2512558375 doi "https://doi.org/10.1016/j.clinre.2016.02.003" @default.
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