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- W2512558866 startingPage "163" @default.
- W2512558866 abstract "Pancreatic cancer is one of the most aggressive malignancies with dismal prognosis. Recently, aspirin has been found to be an effective chemopreventive agent for many solid tumors. However, the function of aspirin use in pancreatic cancer largely remains unknown. We herein argued that aspirin could also lower the risk of pancreatic cancer. Importantly, aspirin assumes pleiotropic effects by targeting multiple molecules. It could further target the unique tumor biology of pancreatic cancer and modify the cancer microenvironment, thus showing remarkable therapeutic potentials. Besides, aspirin could reverse the chemoradiation resistance by repressing tumor repopulation and exert synergistic potentials with metformin on pancreatic cancer chemoprevention. Moreover, aspirin secondarily benefits pancreatic cancer patients through modestly reducing cancer pain and the risk of venous thromboembolism. Furthermore, new aspirin derivatives and delivery systems might help to improve risk-to-benefit ratio. In brief, aspirin is a promising chemopreventive agent and exerts significant therapeutic potentials in pancreatic cancer." @default.
- W2512558866 created "2016-09-16" @default.
- W2512558866 creator A5013862994 @default.
- W2512558866 creator A5034570457 @default.
- W2512558866 creator A5034775273 @default.
- W2512558866 creator A5060120779 @default.
- W2512558866 creator A5063829918 @default.
- W2512558866 date "2016-12-01" @default.
- W2512558866 modified "2023-10-14" @default.
- W2512558866 title "Aspirin in pancreatic cancer: chemopreventive effects and therapeutic potentials" @default.
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