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- W2512578565 abstract "Allogeneic hematopoietic stem cell transplantation (HSCT) is the best post-remission therapy for patients with acute leukemia (AL) at high risk of relapse. Advantages of having a family member as donor include: no undue delay in obtaining the graft; choice of best donor with regards to natural killer (NK) alloreactivity and cytomegalovirus (CMV) status from a panel of candidate family members; easy access to post-transplant cellular therapies like donor lymphocyte infusions and opportunity for a second graft from the original donor, or another family member in case of graft failure. This review will explore how the biological obstacles to HLA-haploidentical (haplo)-HSCT were overcome and how transplant modalities have evolved over time to potentiate the graft-versus-leukemia (GvL) effect in the absence of graft-versus-host disease (GvHD)." @default.
- W2512578565 created "2016-09-16" @default.
- W2512578565 creator A5021123903 @default.
- W2512578565 creator A5089614080 @default.
- W2512578565 date "2016-10-01" @default.
- W2512578565 modified "2023-10-13" @default.
- W2512578565 title "Haploidentical transplants using ex vivo T-cell depletion" @default.
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- W2512578565 doi "https://doi.org/10.1053/j.seminhematol.2016.07.001" @default.
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