FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2512599453> ?p ?o ?g. }

• W2512599453 abstract "Diabetic nephropathy (DN) is the leading cause of renal failure in much of the world. It is a complex disease resulting in pathological changes in various cell types and ultimately culminating in end-stage renal disease. Specifically, mesangial cells (MC) undergo hyperplasia and hypertrophy leading to destruction of the glomerular ultrastructure while also contributing to podocytes loss. Proximal tubule epithelial cells (PTC) undergo similar processes leading to tubulointerstitial fibrosis and also interstitial inflammation. Although these changes are initially propagated by chronic hyperglycaemia, the changes in cellular physiology are elicited via activation and modulation of a wide range of pathways and their products. A central and potent mediator cellular pathophysiology in diabetic nephropathy is TGFβ which is itself upregulated by hyperglycaemia. TGFβ influences many cellular processes and signalling networks. It has becoming increasingly clear that TGFβ mediates its effects in the diabetic kidney through dysregulation of microRNA particularly in MC and PTC, although the extent of these relationships has not been investigated. Despite this, there is still a lack of system biology approaches available for the study of microRNA. Also gaining attention in recent years is the role of mitochondrial dysfunction in the propagation of DN. Although links have been made between TGFβ and mitochondrial function or microRNA expression and mitochondrial function, little has been reported on the influence of TGFβ-mediated microRNA dysregulation on mitochondria. To this end, this thesis has demonstrates and explores the wide reaching effects of TGFβ upon both PTC and MC. The genome wide effect of TGFβ-mediated miRNA dysregulation of the cell wide signalling landscape is also explored. miR-21 is highly dysregulated in PTC and its role in TGFβ-mediated fibrotic signalling is clarified. This effect is clearly defined in regard to the relative contribution of SMAD7 and PTEN. The significance of miR-21 in human DN is also demonstrated. Finally, the role of miR-21 in mitochondrial dysfunction in PTC is proposed to occur at least in part through ACAT1 and AK2. This work adds valuable knowledge to the growing recognition of the importance of microRNA in DN. Furthermore, the development of in silico pipelines may aid those who endeavour to undertake similar projects with the data garnered from such experiments providing an important reference for future investigations. The findings from this thesis are likely to aid in the development of future therapies focusing on retarding the development and progression of DN, not least of all in the rectification of mitochondrial dysfunction and preventing the relentless cycle of fibrotic tissue damage that ultimately results in renal failure. Additional material(s) submitted with thesis." @default.
• W2512599453 created "2016-09-16" @default.
• W2512599453 creator A5044064482 @default.
• W2512599453 date "2016-01-01" @default.
• W2512599453 modified "2023-09-23" @default.
• W2512599453 title "MicroRNA-21 in diabetic nephropathy and a cross-sectional analysis of the role of TGFβ in proximal tubule epithelial cells and mesangial cells" @default.
• W2512599453 doi "https://doi.org/10.4225/03/58b8c5abab3c9" @default.
• W2512599453 hasPublicationYear "2016" @default.
• W2512599453 type Work @default.
• W2512599453 sameAs 2512599453 @default.
• W2512599453 citedByCount "0" @default.
• W2512599453 crossrefType "dissertation" @default.
• W2512599453 hasAuthorship W2512599453A5044064482 @default.
• W2512599453 hasConcept C104317684 @default.
• W2512599453 hasConcept C118131993 @default.
• W2512599453 hasConcept C126322002 @default.
• W2512599453 hasConcept C127561419 @default.
• W2512599453 hasConcept C134018914 @default.
• W2512599453 hasConcept C145059251 @default.
• W2512599453 hasConcept C203014093 @default.
• W2512599453 hasConcept C2776914184 @default.
• W2512599453 hasConcept C2779131090 @default.
• W2512599453 hasConcept C2779922275 @default.
• W2512599453 hasConcept C2780091579 @default.
• W2512599453 hasConcept C2780559512 @default.
• W2512599453 hasConcept C502942594 @default.
• W2512599453 hasConcept C55493867 @default.
• W2512599453 hasConcept C71924100 @default.
• W2512599453 hasConcept C86803240 @default.
• W2512599453 hasConcept C95444343 @default.
• W2512599453 hasConceptScore W2512599453C104317684 @default.
• W2512599453 hasConceptScore W2512599453C118131993 @default.
• W2512599453 hasConceptScore W2512599453C126322002 @default.
• W2512599453 hasConceptScore W2512599453C127561419 @default.
• W2512599453 hasConceptScore W2512599453C134018914 @default.
• W2512599453 hasConceptScore W2512599453C145059251 @default.
• W2512599453 hasConceptScore W2512599453C203014093 @default.
• W2512599453 hasConceptScore W2512599453C2776914184 @default.
• W2512599453 hasConceptScore W2512599453C2779131090 @default.
• W2512599453 hasConceptScore W2512599453C2779922275 @default.
• W2512599453 hasConceptScore W2512599453C2780091579 @default.
• W2512599453 hasConceptScore W2512599453C2780559512 @default.
• W2512599453 hasConceptScore W2512599453C502942594 @default.
• W2512599453 hasConceptScore W2512599453C55493867 @default.
• W2512599453 hasConceptScore W2512599453C71924100 @default.
• W2512599453 hasConceptScore W2512599453C86803240 @default.
• W2512599453 hasConceptScore W2512599453C95444343 @default.
• W2512599453 hasLocation W25125994531 @default.
• W2512599453 hasOpenAccess W2512599453 @default.
• W2512599453 hasPrimaryLocation W25125994531 @default.
• W2512599453 hasRelatedWork W1974150901 @default.
• W2512599453 hasRelatedWork W2009888336 @default.
• W2512599453 hasRelatedWork W2086419185 @default.
• W2512599453 hasRelatedWork W2094062881 @default.
• W2512599453 hasRelatedWork W2097888088 @default.
• W2512599453 hasRelatedWork W2148704680 @default.
• W2512599453 hasRelatedWork W2259516816 @default.
• W2512599453 hasRelatedWork W2334955683 @default.
• W2512599453 hasRelatedWork W2512253971 @default.
• W2512599453 hasRelatedWork W2517894941 @default.
• W2512599453 hasRelatedWork W2604267209 @default.
• W2512599453 hasRelatedWork W2967279669 @default.
• W2512599453 hasRelatedWork W2968872427 @default.
• W2512599453 hasRelatedWork W2981036863 @default.
• W2512599453 hasRelatedWork W3031692491 @default.
• W2512599453 hasRelatedWork W3116827292 @default.
• W2512599453 hasRelatedWork W3123972706 @default.
• W2512599453 hasRelatedWork W3159572455 @default.
• W2512599453 hasRelatedWork W3173632585 @default.
• W2512599453 hasRelatedWork W3185611478 @default.
• W2512599453 isParatext "false" @default.
• W2512599453 isRetracted "false" @default.
• W2512599453 magId "2512599453" @default.
• W2512599453 workType "dissertation" @default.