Matches in SemOpenAlex for { <https://semopenalex.org/work/W2512757939> ?p ?o ?g. }
- W2512757939 endingPage "10333" @default.
- W2512757939 startingPage "10328" @default.
- W2512757939 abstract "Significance Proteinaceous deposits composed primarily of amyloid fibrils of α-synuclein are a hallmark of a range of neurological disorders including Parkinson’s disease. Mutations of the gene encoding α-synuclein have been associated with familial variants of Parkinson’s disease and lead to early- and late-onset forms of the disease. Using a combination of experimental and theoretical approaches specifically designed for the study of α-synuclein, we report that the mutations dramatically affect the rate of lipid-induced fibril production and surface-catalyzed fibril amplification processes. Such a systematic study provides new insights into the influence that single-amino acid replacements in α-synuclein can have on the two steps of α-synuclein aggregation that are likely to be crucial for disease: the initial formation of aggregates and their proliferation." @default.
- W2512757939 created "2016-09-16" @default.
- W2512757939 creator A5005716622 @default.
- W2512757939 creator A5006551440 @default.
- W2512757939 creator A5015741024 @default.
- W2512757939 creator A5021024576 @default.
- W2512757939 creator A5038452125 @default.
- W2512757939 creator A5041530719 @default.
- W2512757939 date "2016-08-29" @default.
- W2512757939 modified "2023-10-11" @default.
- W2512757939 title "Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation" @default.
- W2512757939 cites W1546304837 @default.
- W2512757939 cites W1744659906 @default.
- W2512757939 cites W1815242288 @default.
- W2512757939 cites W1965778124 @default.
- W2512757939 cites W1970577444 @default.
- W2512757939 cites W1973897761 @default.
- W2512757939 cites W1977384016 @default.
- W2512757939 cites W1977846417 @default.
- W2512757939 cites W1982521749 @default.
- W2512757939 cites W2001474652 @default.
- W2512757939 cites W2009556855 @default.
- W2512757939 cites W2014299620 @default.
- W2512757939 cites W2016875890 @default.
- W2512757939 cites W2021977313 @default.
- W2512757939 cites W2022348337 @default.
- W2512757939 cites W2033332906 @default.
- W2512757939 cites W2046127729 @default.
- W2512757939 cites W2047705969 @default.
- W2512757939 cites W2049421402 @default.
- W2512757939 cites W2050375429 @default.
- W2512757939 cites W2050786534 @default.
- W2512757939 cites W2059261643 @default.
- W2512757939 cites W2062562477 @default.
- W2512757939 cites W2066998511 @default.
- W2512757939 cites W2068288454 @default.
- W2512757939 cites W2071574236 @default.
- W2512757939 cites W2072675976 @default.
- W2512757939 cites W2075927534 @default.
- W2512757939 cites W2091265794 @default.
- W2512757939 cites W2094881767 @default.
- W2512757939 cites W2108697350 @default.
- W2512757939 cites W2114636181 @default.
- W2512757939 cites W2115923704 @default.
- W2512757939 cites W2116597539 @default.
- W2512757939 cites W2117503265 @default.
- W2512757939 cites W2121304044 @default.
- W2512757939 cites W2121937669 @default.
- W2512757939 cites W2125553412 @default.
- W2512757939 cites W2133272695 @default.
- W2512757939 cites W2137276641 @default.
- W2512757939 cites W2148910303 @default.
- W2512757939 cites W2150656456 @default.
- W2512757939 cites W2158490078 @default.
- W2512757939 cites W2161334375 @default.
- W2512757939 cites W2164627569 @default.
- W2512757939 cites W2168076805 @default.
- W2512757939 cites W2443158342 @default.
- W2512757939 doi "https://doi.org/10.1073/pnas.1604645113" @default.
- W2512757939 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5027465" @default.
- W2512757939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27573854" @default.
- W2512757939 hasPublicationYear "2016" @default.
- W2512757939 type Work @default.
- W2512757939 sameAs 2512757939 @default.
- W2512757939 citedByCount "219" @default.
- W2512757939 countsByYear W25127579392016 @default.
- W2512757939 countsByYear W25127579392017 @default.
- W2512757939 countsByYear W25127579392018 @default.
- W2512757939 countsByYear W25127579392019 @default.
- W2512757939 countsByYear W25127579392020 @default.
- W2512757939 countsByYear W25127579392021 @default.
- W2512757939 countsByYear W25127579392022 @default.
- W2512757939 countsByYear W25127579392023 @default.
- W2512757939 crossrefType "journal-article" @default.
- W2512757939 hasAuthorship W2512757939A5005716622 @default.
- W2512757939 hasAuthorship W2512757939A5006551440 @default.
- W2512757939 hasAuthorship W2512757939A5015741024 @default.
- W2512757939 hasAuthorship W2512757939A5021024576 @default.
- W2512757939 hasAuthorship W2512757939A5038452125 @default.
- W2512757939 hasAuthorship W2512757939A5041530719 @default.
- W2512757939 hasBestOaLocation W25127579391 @default.
- W2512757939 hasConcept C104317684 @default.
- W2512757939 hasConcept C136238340 @default.
- W2512757939 hasConcept C142724271 @default.
- W2512757939 hasConcept C185592680 @default.
- W2512757939 hasConcept C27523624 @default.
- W2512757939 hasConcept C2777633098 @default.
- W2512757939 hasConcept C2777916540 @default.
- W2512757939 hasConcept C2779134260 @default.
- W2512757939 hasConcept C2779734285 @default.
- W2512757939 hasConcept C2781449126 @default.
- W2512757939 hasConcept C2994168385 @default.
- W2512757939 hasConcept C3019447875 @default.
- W2512757939 hasConcept C501734568 @default.
- W2512757939 hasConcept C54355233 @default.
- W2512757939 hasConcept C59822182 @default.
- W2512757939 hasConcept C71924100 @default.
- W2512757939 hasConcept C86803240 @default.