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• W2512772562 abstract "Abstract Bang-sensitive (BS) Drosophila mutants display characteristic seizure-like activity (SLA) and paralysis after mechanical shock . After high-frequency electrical stimulation (HFS) of the brain, they generate robust seizures at very low threshold voltage. Here we report an important phenomenon, which effectively suppresses SLA in BS mutants. High temperature causes seizure suppression in all BS mutants (parabss1, eas, sda) examined in this study. This effect is fully reversible and flies show complete recovery from BS paralysis once the temperature effect is nullified. High temperature induces an increase in seizure threshold after a brief pulse of heat shock (HS). By genetic screening, we identified the involvement of cAMP in the suppression of seizures by high temperature. We propose that HS induces adenylyl cyclase which in turn increases cAMP concentration which eventually suppresses seizures in mutant flies. In summary, we describe an unusual phenomenon, where high temperature can suppress SLA in flies by modulating cAMP concentration." @default.
• W2512772562 created "2016-09-16" @default.
• W2512772562 creator A5006853795 @default.
• W2512772562 creator A5055182642 @default.
• W2512772562 date "2016-10-01" @default.
• W2512772562 modified "2023-09-27" @default.
• W2512772562 title "Seizure Suppression by High Temperature via cAMP Modulation in<i>Drosophila</i>" @default.
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• W2512772562 doi "https://doi.org/10.1534/g3.116.034629" @default.
• W2512772562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5068957" @default.
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• W2512772562 hasPublicationYear "2016" @default.
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