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- W2512779747 abstract "Five new tigliane diterpene esters (1–5), highly oxygenated tetracyclic diterpenoid carbon skeleton, together with three known analogues (6–8) were isolated from the leaves of Croton tiglium. Extensive NMR and mass spectroscopic analysis were used to elucidate their structures. Most of the isolated compounds were tested for their cytotoxic and antitubercular activities. Among them, the cytotoxic activities of these tigliane-type diterpenes strongly depend on the species of the tumor cells. Especially, these bioactivity compounds showed strong cytotoxic activities against the K562 cell line, and their inhibition effects were close to the positive control Taxol. Furthermore, compounds 1, 2, 6, and 7 showed potent antitubercular activities with MIC values of 19.5, 20.9, 20.5, and 13.4 μM, respectively." @default.
- W2512779747 created "2016-09-16" @default.
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- W2512779747 date "2016-10-01" @default.
- W2512779747 modified "2023-10-02" @default.
- W2512779747 title "Antitubercular and cytotoxic tigliane-type diterpenoids from Croton tiglium" @default.
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- W2512779747 doi "https://doi.org/10.1016/j.bmcl.2016.09.002" @default.
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