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• W2512821594 abstract "MM is a rare and poorly understood cancer with limited therapeutic options. The past decade of research provided a better understanding of the molecular biology and genetics of MM. Translational applications findings so far have been limited and not effective. Malignant mesothelioma (MM) is an aggressive cancer largely associated with asbestos exposure. In this review, we discuss the significant advancements in our understanding of its genetics and molecular biology and their translational relevance. Remarkable findings included the discovery of germline and somatic mutations of BRCA1-associated protein 1 (BAP1) in patients, and the genome-wide characterization of pathways altered in MM that could be exploited to design novel therapeutic approaches. Nevertheless, the clinical translation of these molecular findings has been slow and insufficient. To rapidly move translation from the bench to the bedside, we believe that cooperative research efforts have to be further endorsed and promoted at all levels. Malignant mesothelioma (MM) is an aggressive cancer largely associated with asbestos exposure. In this review, we discuss the significant advancements in our understanding of its genetics and molecular biology and their translational relevance. Remarkable findings included the discovery of germline and somatic mutations of BRCA1-associated protein 1 (BAP1) in patients, and the genome-wide characterization of pathways altered in MM that could be exploited to design novel therapeutic approaches. Nevertheless, the clinical translation of these molecular findings has been slow and insufficient. To rapidly move translation from the bench to the bedside, we believe that cooperative research efforts have to be further endorsed and promoted at all levels." @default.
• W2512821594 created "2016-09-16" @default.
• W2512821594 creator A5000480138 @default.
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• W2512821594 date "2016-09-01" @default.
• W2512821594 modified "2023-10-07" @default.
• W2512821594 title "Malignant Mesothelioma: Time to Translate?" @default.
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• W2512821594 doi "https://doi.org/10.1016/j.trecan.2016.07.004" @default.
• W2512821594 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5461959" @default.
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• W2512821594 hasPublicationYear "2016" @default.
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