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- W2512824732 abstract "Objective Our objective was to investigate how bone metabolism change through body weight gain in women with anorexia nervosa (AN). Patients and methods This retrospective research at one hospital included 36 women with AN (mean age ± SEM, 30 ± 11.3 years, mean BMI ± SEM 12.1 ± 1.2 kg/m2) treated with our CBT program. We measured their bone mineral density (BMD) of the spine and whole body by dual-energy x-ray absorptiometry, serum intact N-terminal propeptide of type 1 procollagen (P1NP), tartrate-resistant acid phosphatase-5b (TRACP-5b) and sclerostin before and after the treatment. Results At baseline, BMD negatively correlated with amenorrhea duration. Upon completion, the body weight increased 8.8 ± 2.9 kg. But they all remained amenorrhea. BMD significantly decreased (posteroanterior spine, –2.7 ± 1.3%; whole body, –1.7 ± 0.5%). Serum intact P1NP levels increased (p Conclusions This study demonstrates that weight gain induces bone formation and reduces bone resorption in women with severe AN regardless of BMD change. Levels of sclerostin at baseline could be a good predictor of reaction of BMD." @default.
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- W2512824732 date "2016-09-01" @default.
- W2512824732 modified "2023-09-27" @default.
- W2512824732 title "How weight gain change bone turnover with women in anorexia nervosa" @default.
- W2512824732 doi "https://doi.org/10.1016/j.ando.2016.07.197" @default.
- W2512824732 hasPublicationYear "2016" @default.
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