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- W2512845642 abstract "Acyclovir is a commonly used antiviral agent for the treatment of herpes simplex and herpes zoster infection. According to the Food and Drug Administration, it is classified as a category B drug and is safe for use during pregnancy [1]. Adverse effects of acyclovir include mild symptoms, such as nausea, vomiting, and diarrhea, to more severe symptoms, including neutropenia, hepatitis, and StevenseJohnson syndrome [2]. Reversible nephrotoxicity can be diagnosed in approximately 5e10% of patients undergoing intravenous (IV) administration. The precipitation of acyclovir crystals results in kidney damage and a rapid rise in serum creatinine [3,4]. However, drug-associated complications during pregnancy have not been documented. A 33-year-old pregnant woman, G2P1, at 31 weeks' gestation presented at the outpatient department with a 2-day history of generalized tiny vesicles on the erythematous base over her trunk and genital area. She was previously started on oral acyclovir (800 mg 4 times daily) under the impression of chickenpox by a dermatologist. Additionally, she reported abdominal tightness, poor intake, and general weakness. Fetal nonstress test showed uterine contractions. The patient was admitted for management of preterm labor in association with chickenpox. Upon admission, her blood pressure was 118/67 mmHg, dipstick test of urinalysis showed trace proteins, and laboratory findings revealed a hemoglobin level of 10.7 g/dL and a hematocrit of 33.9%. The differential counts of lymphocytes and monocytes were 10.7% and 11.2%," @default.
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- W2512845642 date "2016-08-01" @default.
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- W2512845642 title "Acyclovir-induced nephrotoxicity in a pregnant woman with chickenpox" @default.
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- W2512845642 doi "https://doi.org/10.1016/j.tjog.2016.06.012" @default.
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