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- W2512863221 endingPage "780" @default.
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- W2512863221 abstract "Professional American football players incur thousands of repetitive head impacts (RHIs) throughout their lifetime. The long-term consequences of RHI are not well characterized, but may include olfactory dysfunction. RHI has been associated with changes to brain regions involved in olfaction, and olfactory impairment is common after traumatic brain injury. Olfactory dysfunction is a frequent early sequelae of neurodegenerative diseases (e.g., Alzheimer's disease), and RHI is associated with the neurodegenerative disease, chronic traumatic encephalopathy (CTE). We examined olfaction, and its association with clinical measures, in former National Football League (NFL) players. Ninety-five former NFL players (ages 40-69) and 28 same-age controls completed a neuropsychological and neuropsychiatric evaluation as part of a National Institutes of Health-funded study. The Brief Smell Identification Test (B-SIT) assessed olfaction. Principal component analysis generated a four-factor structure of the clinical measures: behavioral/mood, psychomotor speed/executive function, and verbal and visual memory. Former NFL players had worse B-SIT scores relative to controls (p = 0.0096). A B-SIT cutoff of 11 had the greatest accuracy (c-statistic = 0.61) and specificity (79%) for discriminating former NFL players from controls. In the former NFL players, lower B-SIT scores correlated with greater behavioral/mood impairment (p = 0.0254) and worse psychomotor speed/executive functioning (p = 0.0464) after controlling for age and education. Former NFL players exhibited lower olfactory test scores relative to controls, and poorer olfactory test performance was associated with worse neuropsychological and neuropsychiatric functioning. Future work that uses more-comprehensive tests of olfaction and structural and functioning neuroimaging may improve understanding on the association between RHI and olfaction." @default.
- W2512863221 created "2016-09-16" @default.
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- W2512863221 date "2017-02-15" @default.
- W2512863221 modified "2023-09-27" @default.
- W2512863221 title "Olfactory Function and Associated Clinical Correlates in Former National Football League Players" @default.
- W2512863221 cites W1483078865 @default.
- W2512863221 cites W1487849354 @default.
- W2512863221 cites W1512947227 @default.
- W2512863221 cites W1599493014 @default.
- W2512863221 cites W161194141 @default.
- W2512863221 cites W1617802654 @default.
- W2512863221 cites W1856133308 @default.
- W2512863221 cites W1877768494 @default.
- W2512863221 cites W1944945174 @default.
- W2512863221 cites W1965139263 @default.
- W2512863221 cites W1971798204 @default.
- W2512863221 cites W1974384388 @default.
- W2512863221 cites W1974958759 @default.
- W2512863221 cites W1977565007 @default.
- W2512863221 cites W1978845703 @default.
- W2512863221 cites W1981058545 @default.
- W2512863221 cites W1982921548 @default.
- W2512863221 cites W1988504338 @default.
- W2512863221 cites W1996004154 @default.
- W2512863221 cites W1996056398 @default.
- W2512863221 cites W1997480819 @default.
- W2512863221 cites W1997771888 @default.
- W2512863221 cites W1998332829 @default.
- W2512863221 cites W1999654613 @default.
- W2512863221 cites W2000102615 @default.
- W2512863221 cites W2001422009 @default.
- W2512863221 cites W2012946674 @default.
- W2512863221 cites W2013870084 @default.
- W2512863221 cites W2020954880 @default.
- W2512863221 cites W2024132018 @default.
- W2512863221 cites W2043666690 @default.
- W2512863221 cites W2046083322 @default.
- W2512863221 cites W2052280974 @default.
- W2512863221 cites W2059091587 @default.
- W2512863221 cites W2061541290 @default.
- W2512863221 cites W2062964598 @default.
- W2512863221 cites W2065500522 @default.
- W2512863221 cites W2066332029 @default.
- W2512863221 cites W2072625171 @default.
- W2512863221 cites W2072777453 @default.
- W2512863221 cites W2072966173 @default.
- W2512863221 cites W2083213758 @default.
- W2512863221 cites W2084385125 @default.
- W2512863221 cites W2084467453 @default.
- W2512863221 cites W2084627664 @default.
- W2512863221 cites W2098533219 @default.
- W2512863221 cites W2107447135 @default.
- W2512863221 cites W2110282732 @default.
- W2512863221 cites W2111215564 @default.
- W2512863221 cites W2111679543 @default.
- W2512863221 cites W2112778345 @default.
- W2512863221 cites W2114613490 @default.
- W2512863221 cites W2114679345 @default.
- W2512863221 cites W2114811717 @default.
- W2512863221 cites W2116565692 @default.
- W2512863221 cites W2118317725 @default.
- W2512863221 cites W2118675751 @default.
- W2512863221 cites W2120591736 @default.
- W2512863221 cites W2122301128 @default.
- W2512863221 cites W2126271049 @default.
- W2512863221 cites W2126356344 @default.
- W2512863221 cites W2126648090 @default.
- W2512863221 cites W2133242949 @default.
- W2512863221 cites W2141679195 @default.
- W2512863221 cites W2148230634 @default.
- W2512863221 cites W2149897360 @default.
- W2512863221 cites W2155327597 @default.
- W2512863221 cites W2156297351 @default.
- W2512863221 cites W2156511539 @default.
- W2512863221 cites W2160549757 @default.
- W2512863221 cites W2160611136 @default.
- W2512863221 cites W2163431241 @default.
- W2512863221 cites W2174497040 @default.
- W2512863221 cites W2217184110 @default.
- W2512863221 cites W2333552290 @default.
- W2512863221 cites W2376855485 @default.
- W2512863221 cites W2407170318 @default.
- W2512863221 cites W4255323058 @default.
- W2512863221 cites W47270717 @default.
- W2512863221 doi "https://doi.org/10.1089/neu.2016.4536" @default.
- W2512863221 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5314992" @default.
- W2512863221 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27430424" @default.
- W2512863221 hasPublicationYear "2017" @default.