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- W2512865670 abstract "A 64-year-old Filipino man presented with a one-month history of progressive left thigh rigidity and involuntary muscle contraction observed during knee extension, ankle plantarflexion and inversion. Volitional movement and noise aggravated the condition, and prolonged episodes of spasms were associated with pain. This affected ambulation and eventually necessitating the use of crutches. There was increased tone of the rectus femoris, vastus lateralis and vastus medialis muscles of the left leg. All affected muscles were hard on palpation. Marked rigidity was more prominent when patient is observed during ambulation. Neurologic examination was unremarkable. Deep tendon reflexes were normal. Electromyographic and nerve conduction studies (EMG NCV) studies showed sustained interference patterns consisting of normal motor unit action potentials which is consistent with Stiff Person Syndrome. Anti-glutamic acid antibody (anti-GAD Ab) determination was negative. Oral benzodiazepine and baclofen afforded relief of spasms and stiffness and resulted in improvement of functional status. SPS is an important diagnosis to consider in patients presenting with muscle stiffness, spasms and cramps. It may present as a paraneoplastic condition usually associated with lung and breast cancer and may indicate the presence of autoimmune disease. This condition causes significant morbidity and mortality. When properly diagnosed, most cases respond to appropriate treatment resulting to improvement of symptoms. Further investigation for the presence of paraneoplastic conditions especially in seropositive cases is highly recommended." @default.
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- W2512865670 date "2015-10-01" @default.
- W2512865670 modified "2023-10-18" @default.
- W2512865670 title "Stiff person syndrome in a 64 year old male Filipino: a case report" @default.
- W2512865670 doi "https://doi.org/10.1016/j.jns.2015.08.911" @default.
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