Matches in SemOpenAlex for { <https://semopenalex.org/work/W2512996013> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2512996013 abstract "Altered liver function tests are a common finding in clinical practice. Our retrospective study aimed to identify the diagnoses in a non-selected cohort of patients with altered liver tests and to investigate whether alpha-1 antitrypsin genotyping should be part of the diagnostic workup.501 patients who were admitted to our outpatient clinic for further evaluation of altered liver function tests were included in the study. The patients underwent a standardized diagnostic program with history taking, physical examination, laboratory tests and ultrasonography. Liver biopsy was performed if appropriate.More than 50 % of the patients had nonalcoholic fatty liver disease. Alcoholic and drug-induced liver injury were found in 8.6 % and 7 % of patients, respectively. Chronic hepatitis B and C, autoimmune liver disease and inherited causes of liver disease made up for approximately 16 % of the diagnoses. The remaining patients were diagnosed with kryptogenic liver disease or had miscellaneous diagnoses. In 3.7 % of the genotyped patients, the alpha-1 antitrypsin genotype PiMZ was found.Nonalcoholic fatty liver disease is nowadays the most frequent cause of altered liver tests. Alcoholic liver disease might be underrepresented in our study since these patients less often seek medical attention or the diagnosis is already made by the primary care physician. Drug-induced liver injury was found in more patients than expected and might therefore be underdiagnosed in practice. The alpha-1 antitrypsin genotype PiMZ was found in absence of other possible causes of liver disease, indicating that the PiMZ genotype is itself a risk factor for liver disease. Genotyping for alpha-1 antitrypsin should therefore be done when other causes for altered liver function tests have been ruled out." @default.
- W2512996013 created "2016-09-16" @default.
- W2512996013 creator A5033912363 @default.
- W2512996013 creator A5038886503 @default.
- W2512996013 creator A5046262037 @default.
- W2512996013 date "2016-09-09" @default.
- W2512996013 modified "2023-09-27" @default.
- W2512996013 title "Causes of altered liver function tests – the role of alpha-1 antitrypsin" @default.
- W2512996013 doi "https://doi.org/10.1055/s-0042-112033" @default.
- W2512996013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27612218" @default.
- W2512996013 hasPublicationYear "2016" @default.
- W2512996013 type Work @default.
- W2512996013 sameAs 2512996013 @default.
- W2512996013 citedByCount "0" @default.
- W2512996013 crossrefType "journal-article" @default.
- W2512996013 hasAuthorship W2512996013A5033912363 @default.
- W2512996013 hasAuthorship W2512996013A5038886503 @default.
- W2512996013 hasAuthorship W2512996013A5046262037 @default.
- W2512996013 hasConcept C126322002 @default.
- W2512996013 hasConcept C142724271 @default.
- W2512996013 hasConcept C167135981 @default.
- W2512996013 hasConcept C206179267 @default.
- W2512996013 hasConcept C2775934546 @default.
- W2512996013 hasConcept C2776029263 @default.
- W2512996013 hasConcept C2776455275 @default.
- W2512996013 hasConcept C2776637226 @default.
- W2512996013 hasConcept C2776954865 @default.
- W2512996013 hasConcept C2777075537 @default.
- W2512996013 hasConcept C2777214474 @default.
- W2512996013 hasConcept C2777575235 @default.
- W2512996013 hasConcept C2777766500 @default.
- W2512996013 hasConcept C2778772119 @default.
- W2512996013 hasConcept C2779102576 @default.
- W2512996013 hasConcept C2779134260 @default.
- W2512996013 hasConcept C2780535462 @default.
- W2512996013 hasConcept C2780732942 @default.
- W2512996013 hasConcept C2992208098 @default.
- W2512996013 hasConcept C512861765 @default.
- W2512996013 hasConcept C534262118 @default.
- W2512996013 hasConcept C71924100 @default.
- W2512996013 hasConcept C72563966 @default.
- W2512996013 hasConcept C90924648 @default.
- W2512996013 hasConceptScore W2512996013C126322002 @default.
- W2512996013 hasConceptScore W2512996013C142724271 @default.
- W2512996013 hasConceptScore W2512996013C167135981 @default.
- W2512996013 hasConceptScore W2512996013C206179267 @default.
- W2512996013 hasConceptScore W2512996013C2775934546 @default.
- W2512996013 hasConceptScore W2512996013C2776029263 @default.
- W2512996013 hasConceptScore W2512996013C2776455275 @default.
- W2512996013 hasConceptScore W2512996013C2776637226 @default.
- W2512996013 hasConceptScore W2512996013C2776954865 @default.
- W2512996013 hasConceptScore W2512996013C2777075537 @default.
- W2512996013 hasConceptScore W2512996013C2777214474 @default.
- W2512996013 hasConceptScore W2512996013C2777575235 @default.
- W2512996013 hasConceptScore W2512996013C2777766500 @default.
- W2512996013 hasConceptScore W2512996013C2778772119 @default.
- W2512996013 hasConceptScore W2512996013C2779102576 @default.
- W2512996013 hasConceptScore W2512996013C2779134260 @default.
- W2512996013 hasConceptScore W2512996013C2780535462 @default.
- W2512996013 hasConceptScore W2512996013C2780732942 @default.
- W2512996013 hasConceptScore W2512996013C2992208098 @default.
- W2512996013 hasConceptScore W2512996013C512861765 @default.
- W2512996013 hasConceptScore W2512996013C534262118 @default.
- W2512996013 hasConceptScore W2512996013C71924100 @default.
- W2512996013 hasConceptScore W2512996013C72563966 @default.
- W2512996013 hasConceptScore W2512996013C90924648 @default.
- W2512996013 hasLocation W25129960131 @default.
- W2512996013 hasLocation W25129960132 @default.
- W2512996013 hasOpenAccess W2512996013 @default.
- W2512996013 hasPrimaryLocation W25129960131 @default.
- W2512996013 hasRelatedWork W1500505296 @default.
- W2512996013 hasRelatedWork W1539538252 @default.
- W2512996013 hasRelatedWork W1964727784 @default.
- W2512996013 hasRelatedWork W1988745738 @default.
- W2512996013 hasRelatedWork W1989084936 @default.
- W2512996013 hasRelatedWork W2018367530 @default.
- W2512996013 hasRelatedWork W2050371459 @default.
- W2512996013 hasRelatedWork W2050851248 @default.
- W2512996013 hasRelatedWork W2107524597 @default.
- W2512996013 hasRelatedWork W2274052768 @default.
- W2512996013 hasRelatedWork W2383325781 @default.
- W2512996013 hasRelatedWork W2385828697 @default.
- W2512996013 hasRelatedWork W2389876484 @default.
- W2512996013 hasRelatedWork W2403542448 @default.
- W2512996013 hasRelatedWork W2404894295 @default.
- W2512996013 hasRelatedWork W2516465537 @default.
- W2512996013 hasRelatedWork W2888207000 @default.
- W2512996013 hasRelatedWork W2907576011 @default.
- W2512996013 hasRelatedWork W2914319009 @default.
- W2512996013 hasRelatedWork W2184177937 @default.
- W2512996013 isParatext "false" @default.
- W2512996013 isRetracted "false" @default.
- W2512996013 magId "2512996013" @default.
- W2512996013 workType "article" @default.