Matches in SemOpenAlex for { <https://semopenalex.org/work/W2513128214> ?p ?o ?g. }
- W2513128214 endingPage "14" @default.
- W2513128214 startingPage "3" @default.
- W2513128214 abstract "Summary Coordination of endomembrane biogenesis with cell cycle progression is considered to be important in maintaining cell function during growth and development. We previously showed that the disruption of PHOSPHATIDIC ACID PHOSPHOHYDROLASE ( PAH ) activity in Arabidopsis thaliana stimulates biosynthesis of the major phospholipid phosphatidylcholine ( PC ) and causes expansion of the endoplasmic reticulum. Here we show that PC biosynthesis is repressed by disruption of the core cell cycle regulator CYCLIN ‐ DEPENDENT KINASE A;1 ( CDKA ;1) and that this repression is reliant on PAH . Furthermore, we show that cyclin‐dependent kinases ( CDK s) phosphorylate PAH 1 at serine 162, which reduces both its activity and membrane association. Expression of a CDK ‐insensitive version of PAH 1 with a serine 162 to alanine substitution represses PC biosynthesis and also reduces the rate of cell division in early leaf development. Together our findings reveal a physiologically important mechanism that couples the rate of phospholipid biosynthesis and endomembrane biogenesis to cell cycle progression in Arabidopsis." @default.
- W2513128214 created "2016-09-16" @default.
- W2513128214 creator A5015541284 @default.
- W2513128214 creator A5019889453 @default.
- W2513128214 creator A5021248662 @default.
- W2513128214 creator A5028131184 @default.
- W2513128214 creator A5055642199 @default.
- W2513128214 creator A5074153396 @default.
- W2513128214 creator A5086815214 @default.
- W2513128214 date "2016-12-01" @default.
- W2513128214 modified "2023-10-17" @default.
- W2513128214 title "Cyclin-dependent kinase activity enhances phosphatidylcholine biosynthesis in Arabidopsis by repressing phosphatidic acid phosphohydrolase activity" @default.
- W2513128214 cites W1545450687 @default.
- W2513128214 cites W1587455807 @default.
- W2513128214 cites W1919411545 @default.
- W2513128214 cites W1968299201 @default.
- W2513128214 cites W1970544448 @default.
- W2513128214 cites W1971337746 @default.
- W2513128214 cites W1979124782 @default.
- W2513128214 cites W1981323962 @default.
- W2513128214 cites W1985819359 @default.
- W2513128214 cites W1991875570 @default.
- W2513128214 cites W2006595529 @default.
- W2513128214 cites W2008951081 @default.
- W2513128214 cites W2011483704 @default.
- W2513128214 cites W2011632041 @default.
- W2513128214 cites W2011764708 @default.
- W2513128214 cites W2014946189 @default.
- W2513128214 cites W2015218125 @default.
- W2513128214 cites W2015227064 @default.
- W2513128214 cites W2015265398 @default.
- W2513128214 cites W2015340690 @default.
- W2513128214 cites W2015723713 @default.
- W2513128214 cites W2020725477 @default.
- W2513128214 cites W2024178204 @default.
- W2513128214 cites W2031404843 @default.
- W2513128214 cites W2033444013 @default.
- W2513128214 cites W2037605354 @default.
- W2513128214 cites W2037615723 @default.
- W2513128214 cites W2041444673 @default.
- W2513128214 cites W2055589930 @default.
- W2513128214 cites W2057269327 @default.
- W2513128214 cites W2058775690 @default.
- W2513128214 cites W2060166196 @default.
- W2513128214 cites W2071941030 @default.
- W2513128214 cites W2079358631 @default.
- W2513128214 cites W2086275173 @default.
- W2513128214 cites W2088844254 @default.
- W2513128214 cites W2089441009 @default.
- W2513128214 cites W2089466813 @default.
- W2513128214 cites W2096628067 @default.
- W2513128214 cites W2098124605 @default.
- W2513128214 cites W2099529441 @default.
- W2513128214 cites W2102100103 @default.
- W2513128214 cites W2106794605 @default.
- W2513128214 cites W2107627065 @default.
- W2513128214 cites W2110651673 @default.
- W2513128214 cites W2116122104 @default.
- W2513128214 cites W2119993590 @default.
- W2513128214 cites W2122664708 @default.
- W2513128214 cites W2123352057 @default.
- W2513128214 cites W2129214044 @default.
- W2513128214 cites W2136331587 @default.
- W2513128214 cites W2142192445 @default.
- W2513128214 cites W2142376235 @default.
- W2513128214 cites W2142926320 @default.
- W2513128214 cites W2144235090 @default.
- W2513128214 cites W2145367047 @default.
- W2513128214 cites W2151348103 @default.
- W2513128214 cites W2152261949 @default.
- W2513128214 cites W2154061435 @default.
- W2513128214 cites W2154083826 @default.
- W2513128214 cites W2154317408 @default.
- W2513128214 cites W2163340435 @default.
- W2513128214 cites W2164078051 @default.
- W2513128214 cites W2165431281 @default.
- W2513128214 cites W2214764864 @default.
- W2513128214 cites W2231133178 @default.
- W2513128214 cites W2345164574 @default.
- W2513128214 cites W2370044922 @default.
- W2513128214 cites W2794589 @default.
- W2513128214 cites W300688985 @default.
- W2513128214 cites W4247997175 @default.
- W2513128214 doi "https://doi.org/10.1111/tpj.13321" @default.
- W2513128214 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5299491" @default.
- W2513128214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27595588" @default.
- W2513128214 hasPublicationYear "2016" @default.
- W2513128214 type Work @default.
- W2513128214 sameAs 2513128214 @default.
- W2513128214 citedByCount "10" @default.
- W2513128214 countsByYear W25131282142017 @default.
- W2513128214 countsByYear W25131282142018 @default.
- W2513128214 countsByYear W25131282142019 @default.
- W2513128214 countsByYear W25131282142020 @default.
- W2513128214 countsByYear W25131282142022 @default.
- W2513128214 crossrefType "journal-article" @default.
- W2513128214 hasAuthorship W2513128214A5015541284 @default.
- W2513128214 hasAuthorship W2513128214A5019889453 @default.