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• W2513170490 abstract "Background and purpose N ‐acetyl aspartate ( NAA ) assessed using proton magnetic resonance spectroscopy ( 1 H MRS ) has a high pathological specificity for axonal density. Retinal nerve fibre layer thickness ( RNFLT ) measured by using optical coherence tomography is increasingly used as a surrogate marker of neurodegeneration in multiple sclerosis ( MS ). Our aim was to investigate the relation between RNFLT and NAA /creatine in brain normal‐appearing white matter ( NAWM ), their dynamics over time and the association with clinical outcome measures in relapsing MS . T2 WM lesions served as control tissue. Methods Forty‐three MS patients underwent standardized neurological examination including the Expanded Disability Status Scale ( EDSS ), Multiple Sclerosis Functional Composite ( MSFC ) score, optical coherence tomography and magnetic resonance imaging including 1 H MRS at baseline and after 1 year. Results At baseline, NAA /creatine level was lower in T2 WM lesions than in NAWM (1.64 ± 0.16 vs. 1.88 ± 0.24, P < 0.001). Lowest levels were found in secondary progressive MS ( SPMS ). Mean RNFLT was higher in clinically isolated syndrome than in the combined group of relapsing−remitting MS and SPMS (99.8 ± 12.3 μm vs. 92.4 ± 12.8 μm, P = 0.038). In all patients, mean RNFLT decreased by 1.4% during follow‐up. At baseline, MSFC z ‐scores correlated with NAA /creatine levels both in NAWM ( r = 0.42; P = 0.008) and T2 WM lesions ( r = 0.52, P = 0.004). NAWM NAA /creatine variation correlated with the RNFLT change over 1 year ( ρ = 0.43, P = 0.046). Conclusions N ‐acetyl aspartate/creatine level reduction correlated with RNFLT thinning over 1 year in an EDSS stable MS cohort suggesting that these techniques might be sensitive to detect subclinical disease progression." @default.
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• W2513170490 date "2016-09-03" @default.
• W2513170490 modified "2023-09-27" @default.
• W2513170490 title "The association between retinal nerve fibre layer thickness and<i>N</i>-acetyl aspartate levels in multiple sclerosis brain normal-appearing white matter: a longitudinal study using magnetic resonance spectroscopy and optical coherence tomography" @default.
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• W2513170490 doi "https://doi.org/10.1111/ene.13116" @default.
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