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• W2513225897 abstract "This chapter reviews the mechanism by which lysosomal trapping occurs and the drug and cell-related factors that influence the process. It examines some of the techniques used to assess lysosomal trapping in cultured cells. The chapter focuses on the therapeutic implications associated with lysosomal drug sequestration. As discussed, the lysosomal sequestration of drugs can impact the extent of interaction with intracellular targets. Lysosomotropic behavior of drugs has been purposefully exploited in an effort to increase drug potency and selectivity. Moreover, the sequestration of drugs in lysosomes can have a profound impact on the pharmacokinetic properties of drugs. Specifically, lysosomotropic drugs often have large volumes of distribution and, therefore, long elimination half-lives. Finally, the chapter reviews instances where it has been shown that one drug is capable of influencing the lysosomal accumulation of a secondarily administered drug, establishing the basis for a new type of pharmacokinetic drug-drug interaction." @default.
• W2513225897 created "2016-09-16" @default.
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• W2513225897 date "2016-06-27" @default.
• W2513225897 modified "2023-09-23" @default.
• W2513225897 title "The Mechanisms and Therapeutic Consequences of Amine-Containing Drug Sequestration in Lysosomes" @default.
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• W2513225897 doi "https://doi.org/10.1002/9781118978320.ch18" @default.
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