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- W2513226720 abstract "Alzheimer's disease (AD) and semantic dementia (SD) have distinct episodic memory profiles despite the hippocampal atrophy that characterizes both diseases. The aim of this study was to delineate the pattern of gray matter (GM) atrophy associated with AD and SD as well as any differences in these patterns by pooling together the results of previous voxel-based morphometry (VBM) studies.Methods/Overview: We conducted a meta-analysis of VBM studies that investigated GM atrophy in AD patients versus controls (CTRLs) and in SD patients versus CTRLs using the activation likelihood estimation (ALE) approach. Our systematic review allowed us to identify 63 VBM studies.The results confirmed that in addition to the classical cortical pattern of atrophy involving posterior medial and lateral regions in AD and the anterior lateral temporal lobes in SD, both AD and SD patients are characterized by bilateral atrophy of the hippocampus. Furthermore, in SD, the hippocampal atrophy was limited to the anterior portion of the hippocampus, while in AD, both the anterior and posterior parts of the hippocampus exhibited atrophy. When we compared the foci identified in the studies that compared AD patients versus CTRLs with those identified in the studies that compared SD patients versus CTRLs, we observed that the atrophy in the posterior hippocampus and precuneus was more severe in AD.These results support theories that propose that the deficits observed in AD result from damage to the episodic memory network, which involves the posterior hippocampus and posterior medial brain regions. However, sparing of the posterior hippocampus in SD could explain the absence of episodic memory deficits in this population." @default.
- W2513226720 created "2016-09-16" @default.
- W2513226720 creator A5025097218 @default.
- W2513226720 creator A5036550316 @default.
- W2513226720 creator A5065328982 @default.
- W2513226720 creator A5072630801 @default.
- W2513226720 date "2016-10-04" @default.
- W2513226720 modified "2023-10-12" @default.
- W2513226720 title "Atrophy in Alzheimer’s Disease and Semantic Dementia: An ALE Meta-Analysis of Voxel-Based Morphometry Studies" @default.
- W2513226720 cites W1483115913 @default.
- W2513226720 cites W1495263698 @default.
- W2513226720 cites W1538551569 @default.
- W2513226720 cites W1598881740 @default.
- W2513226720 cites W1963686517 @default.
- W2513226720 cites W1965137281 @default.
- W2513226720 cites W1965683618 @default.
- W2513226720 cites W1965774575 @default.
- W2513226720 cites W1966216646 @default.
- W2513226720 cites W1966865971 @default.
- W2513226720 cites W1970488531 @default.
- W2513226720 cites W1974583546 @default.
- W2513226720 cites W1979958927 @default.
- W2513226720 cites W1982934429 @default.
- W2513226720 cites W1982974584 @default.
- W2513226720 cites W1986278330 @default.
- W2513226720 cites W1986672963 @default.
- W2513226720 cites W1988695564 @default.
- W2513226720 cites W1997074193 @default.
- W2513226720 cites W1998728075 @default.
- W2513226720 cites W2005501262 @default.
- W2513226720 cites W2012837809 @default.
- W2513226720 cites W2014930223 @default.
- W2513226720 cites W2016813523 @default.
- W2513226720 cites W2022856253 @default.
- W2513226720 cites W2023168194 @default.
- W2513226720 cites W2023986336 @default.
- W2513226720 cites W2028085829 @default.
- W2513226720 cites W2029886133 @default.
- W2513226720 cites W2031983299 @default.
- W2513226720 cites W2033823029 @default.
- W2513226720 cites W2035938988 @default.
- W2513226720 cites W2039261561 @default.
- W2513226720 cites W2042354978 @default.
- W2513226720 cites W2044491272 @default.
- W2513226720 cites W2045079575 @default.
- W2513226720 cites W2045237617 @default.
- W2513226720 cites W2049688100 @default.
- W2513226720 cites W2050081738 @default.
- W2513226720 cites W2051254098 @default.
- W2513226720 cites W2055748822 @default.
- W2513226720 cites W2057920800 @default.
- W2513226720 cites W2058126937 @default.
- W2513226720 cites W2058949527 @default.
- W2513226720 cites W2060259639 @default.
- W2513226720 cites W2060796157 @default.
- W2513226720 cites W2062469750 @default.
- W2513226720 cites W2065127775 @default.
- W2513226720 cites W2067128590 @default.
- W2513226720 cites W2067462624 @default.
- W2513226720 cites W2067549116 @default.
- W2513226720 cites W2069352717 @default.
- W2513226720 cites W2072315266 @default.
- W2513226720 cites W2072427931 @default.
- W2513226720 cites W2073859273 @default.
- W2513226720 cites W2074815756 @default.
- W2513226720 cites W2074895886 @default.
- W2513226720 cites W2081838509 @default.
- W2513226720 cites W2087167911 @default.
- W2513226720 cites W2087964262 @default.
- W2513226720 cites W2089386742 @default.
- W2513226720 cites W2089596781 @default.
- W2513226720 cites W2089923332 @default.
- W2513226720 cites W2092693001 @default.
- W2513226720 cites W2094567235 @default.
- W2513226720 cites W2094843559 @default.
- W2513226720 cites W2097846342 @default.
- W2513226720 cites W2100997075 @default.
- W2513226720 cites W2102831487 @default.
- W2513226720 cites W2106931873 @default.
- W2513226720 cites W2106974252 @default.
- W2513226720 cites W2111576846 @default.
- W2513226720 cites W2112693804 @default.
- W2513226720 cites W2114790940 @default.
- W2513226720 cites W2115017507 @default.
- W2513226720 cites W2115614582 @default.
- W2513226720 cites W2115886810 @default.
- W2513226720 cites W2116608586 @default.
- W2513226720 cites W2116709840 @default.
- W2513226720 cites W2118421222 @default.
- W2513226720 cites W2119502028 @default.
- W2513226720 cites W2119708734 @default.
- W2513226720 cites W2119848633 @default.
- W2513226720 cites W2121537073 @default.
- W2513226720 cites W2122164674 @default.
- W2513226720 cites W2123819840 @default.
- W2513226720 cites W2127384340 @default.
- W2513226720 cites W2128100315 @default.
- W2513226720 cites W2129637074 @default.