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- W2513238902 abstract "The (URE3) nonchromosomal genetic ele- ment is a prion of Ure2p, a regulator of nitrogen catabolism in Saccharomyces cerevisiae. Ure2p'-65 is the prion domain of Ure2p, sufficient to propagate (URE3) in vivo. We show that full length Ure2p-green fluorescent protein (GFP) or a Ure2pl-65-GFP fusion protein is aggregated in cells carrying (URE3) but is evenly distributed in cells lacking the (URE3) prion. This indicates that (URE3) involves a self-propagating aggregation of Ure2p. Overexpression of Ure2p'-65 induces the de novo appearance of (URE3) by 1,000-fold in a strain initially (ure-o), but cures (URE3) from a strain initially carrying the (URE3) prion. Overexpression of several other fragments of Ure2p or Ure2-GFP fusion proteins also effi- ciently cures the prion. We suggest that incorporation of fragments or fusion proteins into a putative (URE3) crystal of Ure2p poisons its propagation." @default.
- W2513238902 created "2016-09-16" @default.
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- W2513238902 date "2016-01-01" @default.
- W2513238902 modified "2023-09-27" @default.
- W2513238902 title "The (URE3) prion is an aggregate cured by overexpression of Ure2)" @default.
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