FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2513254528> ?p ?o ?g. }

• W2513254528 endingPage "e814" @default.
• W2513254528 startingPage "e807" @default.
• W2513254528 abstract "Purpose: To evaluate the efficacy of rho-associated protein kinase inhibitor, AR-12286 topical solution, for its effect in eyes with exfoliation syndrome (XFS) and ocular hypertension (OHT) or exfoliative glaucoma (XFG) and examine any lasting effect on intraocular pressure (IOP) after discontinuation. Methods: Prospective, double-masked, randomized, interventional study. Patients with XFS and OHT or XFG were enrolled. The study eyes were treated once daily with AR-12286, randomized to 0.5% or 0.7% for 24 weeks. Visits included baseline, 1, 4, and 12 weeks after drug initiation; at 12 weeks AR-12286 was discontinued for 1 week and was resumed at week 13. At the week 24 visit, AR-12286 was discontinued, and a final reexamination was performed at week 25. Results: Ten patients were treated. Mean baseline IOP was 25±2.4 mm Hg, mean IOP was reduced to 19.1±2.3 mm Hg at 1 week ( P <0.001), 17.5±3.6 mm Hg at 4 weeks ( P <0.001), and 17.4±3.6 mm Hg at 12 weeks ( P <0.001), yielding an average IOP reduction of 23.6%, 30%, and 30.4%, respectively. At the week 13 visit, 1 week after the drug was discontinued, mean IOP increased to 21.6±5.4 mm Hg ( P =0.06 compared with baseline visit). At week 24, the mean IOP was 21.8±7.8 mm Hg ( P =0.2, and AR-12286 was discontinued). At week 25, the mean IOP was 21.3±5.3 mm Hg ( P =0.06). Conclusions: AR-12286 was well tolerated and provided statistically significant reduction in IOP in patients with XFS and OHT or XFG. This drug may represent an additional therapeutic paradigm for the treatment of XFG." @default.
• W2513254528 created "2016-09-16" @default.
• W2513254528 creator A5014086522 @default.
• W2513254528 creator A5017316846 @default.
• W2513254528 creator A5059716407 @default.
• W2513254528 date "2016-09-01" @default.
• W2513254528 modified "2023-10-11" @default.
• W2513254528 title "Efficacy of Topically Administered Rho-Kinase Inhibitor AR-12286 in Patients With Exfoliation Syndrome and Ocular Hypertension or Glaucoma" @default.
• W2513254528 cites W1493994445 @default.
• W2513254528 cites W1597787921 @default.
• W2513254528 cites W1918082152 @default.
• W2513254528 cites W1968584313 @default.
• W2513254528 cites W1977438029 @default.
• W2513254528 cites W1984210761 @default.
• W2513254528 cites W1984653721 @default.
• W2513254528 cites W1985564676 @default.
• W2513254528 cites W1990804068 @default.
• W2513254528 cites W1995757732 @default.
• W2513254528 cites W2000188822 @default.
• W2513254528 cites W2001552905 @default.
• W2513254528 cites W2006716128 @default.
• W2513254528 cites W2008029604 @default.
• W2513254528 cites W2008286480 @default.
• W2513254528 cites W2017227447 @default.
• W2513254528 cites W2021892546 @default.
• W2513254528 cites W2022099686 @default.
• W2513254528 cites W2025032550 @default.
• W2513254528 cites W2031049195 @default.
• W2513254528 cites W2032295238 @default.
• W2513254528 cites W2033049859 @default.
• W2513254528 cites W2044892935 @default.
• W2513254528 cites W2052074844 @default.
• W2513254528 cites W2060999873 @default.
• W2513254528 cites W2062184678 @default.
• W2513254528 cites W2077603983 @default.
• W2513254528 cites W2077979328 @default.
• W2513254528 cites W2078558359 @default.
• W2513254528 cites W2079962716 @default.
• W2513254528 cites W2080097627 @default.
• W2513254528 cites W2085002639 @default.
• W2513254528 cites W2093247746 @default.
• W2513254528 cites W2094184267 @default.
• W2513254528 cites W2096730217 @default.
• W2513254528 cites W2096791952 @default.
• W2513254528 cites W2098617215 @default.
• W2513254528 cites W2098703441 @default.
• W2513254528 cites W2114312123 @default.
• W2513254528 cites W2118359262 @default.
• W2513254528 cites W2118735497 @default.
• W2513254528 cites W2151395669 @default.
• W2513254528 cites W2166813012 @default.
• W2513254528 cites W2327333154 @default.
• W2513254528 cites W4211012086 @default.
• W2513254528 cites W2044186800 @default.
• W2513254528 doi "https://doi.org/10.1097/ijg.0000000000000508" @default.
• W2513254528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27552517" @default.
• W2513254528 hasPublicationYear "2016" @default.
• W2513254528 type Work @default.
• W2513254528 sameAs 2513254528 @default.
• W2513254528 citedByCount "19" @default.
• W2513254528 countsByYear W25132545282017 @default.
• W2513254528 countsByYear W25132545282018 @default.
• W2513254528 countsByYear W25132545282019 @default.
• W2513254528 countsByYear W25132545282020 @default.
• W2513254528 countsByYear W25132545282021 @default.
• W2513254528 countsByYear W25132545282022 @default.
• W2513254528 countsByYear W25132545282023 @default.
• W2513254528 crossrefType "journal-article" @default.
• W2513254528 hasAuthorship W2513254528A5014086522 @default.
• W2513254528 hasAuthorship W2513254528A5017316846 @default.
• W2513254528 hasAuthorship W2513254528A5059716407 @default.
• W2513254528 hasConcept C118487528 @default.
• W2513254528 hasConcept C126322002 @default.
• W2513254528 hasConcept C168563851 @default.
• W2513254528 hasConcept C188816634 @default.
• W2513254528 hasConcept C2776521421 @default.
• W2513254528 hasConcept C2778527774 @default.
• W2513254528 hasConcept C2778715236 @default.
• W2513254528 hasConcept C2781092963 @default.
• W2513254528 hasConcept C71924100 @default.
• W2513254528 hasConceptScore W2513254528C118487528 @default.
• W2513254528 hasConceptScore W2513254528C126322002 @default.
• W2513254528 hasConceptScore W2513254528C168563851 @default.
• W2513254528 hasConceptScore W2513254528C188816634 @default.
• W2513254528 hasConceptScore W2513254528C2776521421 @default.
• W2513254528 hasConceptScore W2513254528C2778527774 @default.
• W2513254528 hasConceptScore W2513254528C2778715236 @default.
• W2513254528 hasConceptScore W2513254528C2781092963 @default.
• W2513254528 hasConceptScore W2513254528C71924100 @default.
• W2513254528 hasIssue "9" @default.
• W2513254528 hasLocation W25132545281 @default.
• W2513254528 hasLocation W25132545282 @default.
• W2513254528 hasOpenAccess W2513254528 @default.
• W2513254528 hasPrimaryLocation W25132545281 @default.
• W2513254528 hasRelatedWork W187977929 @default.
• W2513254528 hasRelatedWork W1985003929 @default.
• W2513254528 hasRelatedWork W1996537036 @default.
• W2513254528 hasRelatedWork W2022378535 @default.

• next