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- W2513323604 abstract "Type III collagen is a fibrillar collagen, and it consists of only one collagen α chain, in contrast to most other collagens. It is a homotrimer containing three α1(III) chains supercoiled around each other in a right-handed triple helix. Type III collagen is secreted by fibroblasts and other mesenchymal cell types, thus making it a major player in various inflammation-associated pathologies such as lung injury, viral and nonviral liver diseases, kidney fibrosis, hernia, and vascular disorders. Type III collagen together with type I collagen are the main constituents of the interstitial matrix. Type III collagen mutations are associated with Ehlers–Danlos syndrome, vascular deficiency, and aortic and arterial aneurysms. Several biomarkers for type III collagen formation and degradation have been developed and used extensively. In particular, for fibrosis, type III collagen formations have proven valuable." @default.
- W2513323604 created "2016-09-16" @default.
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- W2513323604 date "2016-01-01" @default.
- W2513323604 modified "2023-10-18" @default.
- W2513323604 title "Type III Collagen" @default.
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- W2513323604 doi "https://doi.org/10.1016/b978-0-12-809847-9.00003-9" @default.
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