Matches in SemOpenAlex for { <https://semopenalex.org/work/W2513360005> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2513360005 abstract "Ocular surface diseases are among the most frequent ocular pathologies, with prevalence ranging from 20% of the general population. Ocular pain following corneal injury is frequently observed in clinic. Here we characterized the peripheral and central neuroinflammatory process in the trigeminal pathways in response to ocular pain. We used topical instillations of 0.2% benzalkonium chloride (BAC) in mice for 7 days. BAC-treated animals developed severe dry eye (reduced tear production and inflammation in the cornea). Hypertonic saline-evoked eye wipe behavior was enhanced in BAC-treated animals. We reported an increased ATF3, FOS and Iba1 immunoreactivity and higher IL-6 and TNF- α mRNA levels in the trigeminal ganglion. Interestingly, the sensory trigeminal complex at the ipsilateral interpolaris/caudalis (Vi/Vc) transition and Vc/upper cervical cord (Vc/C1) regions exhibited higher FOS and Iba1 positive cells in BAC animals. Activated microglial cells were tightly wrapped around activated FOS neurons in both regions. Furthermore, phosphorylated p38 MAPK was markedly enhanced in microglial cells during ocular inflammation. These neuroanatomical data correlated with the increase in mRNA expression of pro-inflammatory (TNF- α , IL-6, CCL2) and neuronal (FOS and ATF3) markers. This work provides the demonstration that corneal inflammation provokes central neuroinflammatory process. Thus, altered activity in intracellular signaling caused by ocular inflammation might play a priming role in the central sensitization of ocular related brainstem circuits, which represents a significant factor in ocular pain development." @default.
- W2513360005 created "2016-09-16" @default.
- W2513360005 creator A5017573517 @default.
- W2513360005 creator A5057620589 @default.
- W2513360005 creator A5059621474 @default.
- W2513360005 creator A5070820842 @default.
- W2513360005 creator A5071197560 @default.
- W2513360005 creator A5071307640 @default.
- W2513360005 creator A5073947287 @default.
- W2513360005 creator A5083090366 @default.
- W2513360005 creator A5088789227 @default.
- W2513360005 creator A5091656060 @default.
- W2513360005 date "2016-10-01" @default.
- W2513360005 modified "2023-10-18" @default.
- W2513360005 title "Abstract # 1835 Corneal injury induces trigeminal pain, peripheral and central neuroinflammatory process" @default.
- W2513360005 doi "https://doi.org/10.1016/j.bbi.2016.07.120" @default.
- W2513360005 hasPublicationYear "2016" @default.
- W2513360005 type Work @default.
- W2513360005 sameAs 2513360005 @default.
- W2513360005 citedByCount "0" @default.
- W2513360005 crossrefType "journal-article" @default.
- W2513360005 hasAuthorship W2513360005A5017573517 @default.
- W2513360005 hasAuthorship W2513360005A5057620589 @default.
- W2513360005 hasAuthorship W2513360005A5059621474 @default.
- W2513360005 hasAuthorship W2513360005A5070820842 @default.
- W2513360005 hasAuthorship W2513360005A5071197560 @default.
- W2513360005 hasAuthorship W2513360005A5071307640 @default.
- W2513360005 hasAuthorship W2513360005A5073947287 @default.
- W2513360005 hasAuthorship W2513360005A5083090366 @default.
- W2513360005 hasAuthorship W2513360005A5088789227 @default.
- W2513360005 hasAuthorship W2513360005A5091656060 @default.
- W2513360005 hasConcept C126322002 @default.
- W2513360005 hasConcept C15490471 @default.
- W2513360005 hasConcept C169760540 @default.
- W2513360005 hasConcept C170493617 @default.
- W2513360005 hasConcept C203014093 @default.
- W2513360005 hasConcept C2776352249 @default.
- W2513360005 hasConcept C2776700747 @default.
- W2513360005 hasConcept C2776914184 @default.
- W2513360005 hasConcept C2779830541 @default.
- W2513360005 hasConcept C2908647359 @default.
- W2513360005 hasConcept C3017567848 @default.
- W2513360005 hasConcept C42219234 @default.
- W2513360005 hasConcept C71924100 @default.
- W2513360005 hasConcept C86803240 @default.
- W2513360005 hasConcept C94487597 @default.
- W2513360005 hasConcept C99454951 @default.
- W2513360005 hasConceptScore W2513360005C126322002 @default.
- W2513360005 hasConceptScore W2513360005C15490471 @default.
- W2513360005 hasConceptScore W2513360005C169760540 @default.
- W2513360005 hasConceptScore W2513360005C170493617 @default.
- W2513360005 hasConceptScore W2513360005C203014093 @default.
- W2513360005 hasConceptScore W2513360005C2776352249 @default.
- W2513360005 hasConceptScore W2513360005C2776700747 @default.
- W2513360005 hasConceptScore W2513360005C2776914184 @default.
- W2513360005 hasConceptScore W2513360005C2779830541 @default.
- W2513360005 hasConceptScore W2513360005C2908647359 @default.
- W2513360005 hasConceptScore W2513360005C3017567848 @default.
- W2513360005 hasConceptScore W2513360005C42219234 @default.
- W2513360005 hasConceptScore W2513360005C71924100 @default.
- W2513360005 hasConceptScore W2513360005C86803240 @default.
- W2513360005 hasConceptScore W2513360005C94487597 @default.
- W2513360005 hasConceptScore W2513360005C99454951 @default.
- W2513360005 hasLocation W25133600051 @default.
- W2513360005 hasOpenAccess W2513360005 @default.
- W2513360005 hasPrimaryLocation W25133600051 @default.
- W2513360005 hasRelatedWork W1669905351 @default.
- W2513360005 hasRelatedWork W1973413068 @default.
- W2513360005 hasRelatedWork W1996798294 @default.
- W2513360005 hasRelatedWork W2000357387 @default.
- W2513360005 hasRelatedWork W2005454266 @default.
- W2513360005 hasRelatedWork W2018654459 @default.
- W2513360005 hasRelatedWork W2052400493 @default.
- W2513360005 hasRelatedWork W2058377405 @default.
- W2513360005 hasRelatedWork W2084928699 @default.
- W2513360005 hasRelatedWork W2085666180 @default.
- W2513360005 hasRelatedWork W2206572702 @default.
- W2513360005 hasRelatedWork W2345607868 @default.
- W2513360005 hasRelatedWork W2586021754 @default.
- W2513360005 hasRelatedWork W2809204156 @default.
- W2513360005 hasRelatedWork W2974394802 @default.
- W2513360005 hasRelatedWork W2981849470 @default.
- W2513360005 hasRelatedWork W3003280862 @default.
- W2513360005 hasRelatedWork W3018601024 @default.
- W2513360005 hasRelatedWork W3093849878 @default.
- W2513360005 hasRelatedWork W3146985243 @default.
- W2513360005 isParatext "false" @default.
- W2513360005 isRetracted "false" @default.
- W2513360005 magId "2513360005" @default.
- W2513360005 workType "article" @default.