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- W2513378203 abstract "<b><i>Background:</i></b> The treatment of severe morphea is challenging, and treatment experience concerning the use of immunosuppressive agents for this condition is limited. <b><i>Objective:</i></b> The purpose of this study is to analyze the use of cyclosporine, its tolerability, and its effect on skin sclerosis. <b><i>Materials and Methods:</i></b> Patients with severe morphea who underwent treatment with cyclosporine were studied retrospectively. <b><i>Results:</i></b> Five of 12 patients with morphea showed complete remission and 6 patients had partial remission at the end of therapy (9-46 months, median 14) under a median cyclosporine dose of 2.4 mg/kg. The mean affected body surface area fell from 50% (2-80, median 65) to 17% (0-40, median 18). Side effects were hypertension, elevated transaminases, cholesterol, and weight gain. <b><i>Conclusion:</i></b> Cyclosporine can be effective in morphea. The side effects were reversible. However, the duration of treatment with cyclosporine is limited because of its potential permanent side effects. Prospective placebo-controlled studies are needed to establish the superiority of cyclosporine over other immunosuppressive drugs in this setting." @default.
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- W2513378203 date "2016-01-01" @default.
- W2513378203 modified "2023-10-17" @default.
- W2513378203 title "Cyclosporine Reduces Sclerosis in Morphea: A Retrospective Study in 12 Patients and a Literature Review" @default.
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- W2513378203 doi "https://doi.org/10.1159/000448171" @default.
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