Matches in SemOpenAlex for { <https://semopenalex.org/work/W2513490781> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2513490781 abstract "Impaired sense of smell is a common symptom of various neurological and psychiatric diseases. However, how olfactory dysfunction is associated with these disorders remains unknown. Since nasopharynx is an entry site for environmental agents, we hypothesized that nasal mucosal inflammation initiated by environmental toxin is transmitted to the brain via the olfactory neural pathway and contributes to neurodegeneration. Adult male mice received multiple injections with 10 μL of lipopolysaccharide (LPS) (1 mg/mL) into the unilateral nasal cavity every other day. Mice were fixed at 1, 3, 7, 14 and 21 days after the first injection and subjected to immunohistological analyses. Intranasal LPS induced neutrophils and monocytes infiltration into the lateral part of the olfactory epithelium (OE) from Day 1. Some monocytes but not neutrophils released IL-1 beta. Olfactory sensory neurons were gradually damaged time-dependently. In addition, neutrophil infiltration into the olfactory nerve layer and the glomerular layer (GL) as well as activation of microglia and astrocytes were evident in the lateral part of the olfactory bulb (OB). At Day 21, immunoreactivity for tyrosine hydroxylase around the GL and that for a synaptic marker in the external plexiform were reduced in the LPS injected side. These results indicate that LPS-induced olfactory epithelial inflammation is transmitted to the OB along the olfactory neural pathway. Neuroinflammation in other brain regions are being studied." @default.
- W2513490781 created "2016-09-16" @default.
- W2513490781 creator A5008058192 @default.
- W2513490781 creator A5051236045 @default.
- W2513490781 creator A5069083804 @default.
- W2513490781 date "2016-10-01" @default.
- W2513490781 modified "2023-09-27" @default.
- W2513490781 title "Abstract # 1788 Propagation of endotoxin-induced nasal mucosal inflammation to the olfactory bulb along the olfactory neural pathway" @default.
- W2513490781 doi "https://doi.org/10.1016/j.bbi.2016.07.081" @default.
- W2513490781 hasPublicationYear "2016" @default.
- W2513490781 type Work @default.
- W2513490781 sameAs 2513490781 @default.
- W2513490781 citedByCount "0" @default.
- W2513490781 crossrefType "journal-article" @default.
- W2513490781 hasAuthorship W2513490781A5008058192 @default.
- W2513490781 hasAuthorship W2513490781A5051236045 @default.
- W2513490781 hasAuthorship W2513490781A5069083804 @default.
- W2513490781 hasConcept C105702510 @default.
- W2513490781 hasConcept C121332964 @default.
- W2513490781 hasConcept C134018914 @default.
- W2513490781 hasConcept C142724271 @default.
- W2513490781 hasConcept C153400128 @default.
- W2513490781 hasConcept C163214680 @default.
- W2513490781 hasConcept C169760540 @default.
- W2513490781 hasConcept C201792869 @default.
- W2513490781 hasConcept C203014093 @default.
- W2513490781 hasConcept C2776886281 @default.
- W2513490781 hasConcept C2776914184 @default.
- W2513490781 hasConcept C2778801703 @default.
- W2513490781 hasConcept C2779830541 @default.
- W2513490781 hasConcept C2780187430 @default.
- W2513490781 hasConcept C2780496858 @default.
- W2513490781 hasConcept C2781377823 @default.
- W2513490781 hasConcept C529278444 @default.
- W2513490781 hasConcept C71924100 @default.
- W2513490781 hasConcept C85663871 @default.
- W2513490781 hasConcept C86803240 @default.
- W2513490781 hasConcept C87753298 @default.
- W2513490781 hasConcept C97355855 @default.
- W2513490781 hasConceptScore W2513490781C105702510 @default.
- W2513490781 hasConceptScore W2513490781C121332964 @default.
- W2513490781 hasConceptScore W2513490781C134018914 @default.
- W2513490781 hasConceptScore W2513490781C142724271 @default.
- W2513490781 hasConceptScore W2513490781C153400128 @default.
- W2513490781 hasConceptScore W2513490781C163214680 @default.
- W2513490781 hasConceptScore W2513490781C169760540 @default.
- W2513490781 hasConceptScore W2513490781C201792869 @default.
- W2513490781 hasConceptScore W2513490781C203014093 @default.
- W2513490781 hasConceptScore W2513490781C2776886281 @default.
- W2513490781 hasConceptScore W2513490781C2776914184 @default.
- W2513490781 hasConceptScore W2513490781C2778801703 @default.
- W2513490781 hasConceptScore W2513490781C2779830541 @default.
- W2513490781 hasConceptScore W2513490781C2780187430 @default.
- W2513490781 hasConceptScore W2513490781C2780496858 @default.
- W2513490781 hasConceptScore W2513490781C2781377823 @default.
- W2513490781 hasConceptScore W2513490781C529278444 @default.
- W2513490781 hasConceptScore W2513490781C71924100 @default.
- W2513490781 hasConceptScore W2513490781C85663871 @default.
- W2513490781 hasConceptScore W2513490781C86803240 @default.
- W2513490781 hasConceptScore W2513490781C87753298 @default.
- W2513490781 hasConceptScore W2513490781C97355855 @default.
- W2513490781 hasLocation W25134907811 @default.
- W2513490781 hasOpenAccess W2513490781 @default.
- W2513490781 hasPrimaryLocation W25134907811 @default.
- W2513490781 hasRelatedWork W108754074 @default.
- W2513490781 hasRelatedWork W1966792643 @default.
- W2513490781 hasRelatedWork W1968225758 @default.
- W2513490781 hasRelatedWork W1981500872 @default.
- W2513490781 hasRelatedWork W1988128651 @default.
- W2513490781 hasRelatedWork W2004768834 @default.
- W2513490781 hasRelatedWork W2005989568 @default.
- W2513490781 hasRelatedWork W2021270083 @default.
- W2513490781 hasRelatedWork W2035842950 @default.
- W2513490781 hasRelatedWork W2047490337 @default.
- W2513490781 hasRelatedWork W2050094778 @default.
- W2513490781 hasRelatedWork W2078176549 @default.
- W2513490781 hasRelatedWork W2082431605 @default.
- W2513490781 hasRelatedWork W2083223419 @default.
- W2513490781 hasRelatedWork W2118442642 @default.
- W2513490781 hasRelatedWork W2141987458 @default.
- W2513490781 hasRelatedWork W2370073514 @default.
- W2513490781 hasRelatedWork W2387119190 @default.
- W2513490781 hasRelatedWork W2938074699 @default.
- W2513490781 hasRelatedWork W3043275360 @default.
- W2513490781 isParatext "false" @default.
- W2513490781 isRetracted "false" @default.
- W2513490781 magId "2513490781" @default.
- W2513490781 workType "article" @default.