FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2513521719> ?p ?o ?g. }

• W2513521719 endingPage "383" @default.
• W2513521719 startingPage "369" @default.
• W2513521719 abstract "Injection of goldthioglucose (GTG) destroys the bilateral ventro-medial nucleus, the “satiety area” and gives rise to hypothalamic obesity in mice (abbreated later as GTG mice).A considerable number of papers have been published on lipid metabolism of liver and adipose tissue in these obese animal. However, little is known about individual fatty acids synthesis in GTG mice.In this report, the author disclosed the individual fatty acids synthesis of liver and adipose tissue in GTG mice.Observations were performed both in vitro and in vivo, with analysis of the incorporation and distribution of 1-14C-acetate in individual fatty acids of major lipid classesResults were as follows.Experiment on liver;1) Liver of GTG mice incorporated significantly more 1-14C-acetate in saponifiable fraction of lipids (=total fatty acids) than liver of control mice did.2) In regard to the study on the distribution of 1-14C-acetate in individual fatty acids separated by gaschromatography, the percentage of radioactivity recovered in oleic acid significantly increased in GTG mice. On the other hand, the percentage of radioactivity in fatty acids with retention time corresponding to arachidic acid or longer relatively decreased.3) After four hours' incubation of liver with 1-14C-acetate in vitro, the percentage distribution of radioactivity recovered in triglyceride significantly increased in GTG mice compared with control mice.In vivo, the percentage distribution of radioactivity increased in liver triglyceride with time from one hour to four hours after administration of 1-14C-acetate in GTG mice.4) It is conspicuous that the amount of radioactivity recovered in oleic acid of GTG mice was always significantly higher than in that of control mice, on analysis of 14C distribution in individual fatty acids esterified into triglyceride, both in vitro and in vivo.The percentage distribution of 14C in oleic acid of triglyceride in GTG mice was increasing with time up to four hours in vivo, too.5) In individual fatty acids esterified into phospholipids, the percentage of 14C found in oleic acid of GTG mice was also higher than in that of control mice.6) In vitro, fasted animals incorporated less 14C into total fatty acids than fed animals in both GTG and control mice and significant decrease was observed in the percentage of 14C in myristic acid and palmitic acid.Experiment on adipose tissue;There was a highly significant increase in the incorporation of 14C into total fatty acids in the tissue of GTG mice compared with control mice.However, no significant differences were found in the percentage distribution of 14C in major lipid classes nor in individual fatty acids of saponifiable fraction of lipids between both groups of mice.From these results, the author advocates a possibility that obesity of these animals is due to the increased synthesis of fatty acids and incresed accumulation of triglyceride esterified with oleic acid." @default.
• W2513521719 created "2016-09-16" @default.
• W2513521719 creator A5089503656 @default.
• W2513521719 date "1974-01-01" @default.
• W2513521719 modified "2023-09-27" @default.
• W2513521719 title "Studies on Fatty Acids Metabolism of Goldthioglucose Obese Mice" @default.
• W2513521719 cites W1560037002 @default.
• W2513521719 cites W1570047590 @default.
• W2513521719 cites W1581324561 @default.
• W2513521719 cites W1602139825 @default.
• W2513521719 cites W16319407 @default.
• W2513521719 cites W1694959295 @default.
• W2513521719 cites W1813279008 @default.
• W2513521719 cites W1822895582 @default.
• W2513521719 cites W1885155177 @default.
• W2513521719 cites W1999087964 @default.
• W2513521719 cites W2010222067 @default.
• W2513521719 cites W2018021114 @default.
• W2513521719 cites W2030792580 @default.
• W2513521719 cites W2039318319 @default.
• W2513521719 cites W2057083611 @default.
• W2513521719 cites W2058272150 @default.
• W2513521719 cites W2061815762 @default.
• W2513521719 cites W2072370509 @default.
• W2513521719 cites W2072547635 @default.
• W2513521719 cites W2105890957 @default.
• W2513521719 cites W2118718490 @default.
• W2513521719 cites W2137113565 @default.
• W2513521719 cites W2142838476 @default.
• W2513521719 cites W2168526937 @default.
• W2513521719 cites W2183399359 @default.
• W2513521719 cites W2322980330 @default.
• W2513521719 cites W2332084034 @default.
• W2513521719 cites W2404325132 @default.
• W2513521719 cites W2410192292 @default.
• W2513521719 cites W2412649805 @default.
• W2513521719 cites W2413165420 @default.
• W2513521719 cites W2415090381 @default.
• W2513521719 cites W2415842426 @default.
• W2513521719 cites W2471177820 @default.
• W2513521719 cites W2479340407 @default.
• W2513521719 cites W646980114 @default.
• W2513521719 doi "https://doi.org/10.4044/joma1947.86.7-8_369" @default.
• W2513521719 hasPublicationYear "1974" @default.
• W2513521719 type Work @default.
• W2513521719 sameAs 2513521719 @default.
• W2513521719 citedByCount "0" @default.
• W2513521719 crossrefType "journal-article" @default.
• W2513521719 hasAuthorship W2513521719A5089503656 @default.
• W2513521719 hasBestOaLocation W25135217191 @default.
• W2513521719 hasConcept C126322002 @default.
• W2513521719 hasConcept C134018914 @default.
• W2513521719 hasConcept C150903083 @default.
• W2513521719 hasConcept C171089720 @default.
• W2513521719 hasConcept C185592680 @default.
• W2513521719 hasConcept C207001950 @default.
• W2513521719 hasConcept C2778163477 @default.
• W2513521719 hasConcept C2778220968 @default.
• W2513521719 hasConcept C2778772119 @default.
• W2513521719 hasConcept C2778913445 @default.
• W2513521719 hasConcept C2779134260 @default.
• W2513521719 hasConcept C2779936771 @default.
• W2513521719 hasConcept C2781403372 @default.
• W2513521719 hasConcept C4733338 @default.
• W2513521719 hasConcept C543025807 @default.
• W2513521719 hasConcept C55493867 @default.
• W2513521719 hasConcept C62231903 @default.
• W2513521719 hasConcept C71924100 @default.
• W2513521719 hasConcept C86803240 @default.
• W2513521719 hasConceptScore W2513521719C126322002 @default.
• W2513521719 hasConceptScore W2513521719C134018914 @default.
• W2513521719 hasConceptScore W2513521719C150903083 @default.
• W2513521719 hasConceptScore W2513521719C171089720 @default.
• W2513521719 hasConceptScore W2513521719C185592680 @default.
• W2513521719 hasConceptScore W2513521719C207001950 @default.
• W2513521719 hasConceptScore W2513521719C2778163477 @default.
• W2513521719 hasConceptScore W2513521719C2778220968 @default.
• W2513521719 hasConceptScore W2513521719C2778772119 @default.
• W2513521719 hasConceptScore W2513521719C2778913445 @default.
• W2513521719 hasConceptScore W2513521719C2779134260 @default.
• W2513521719 hasConceptScore W2513521719C2779936771 @default.
• W2513521719 hasConceptScore W2513521719C2781403372 @default.
• W2513521719 hasConceptScore W2513521719C4733338 @default.
• W2513521719 hasConceptScore W2513521719C543025807 @default.
• W2513521719 hasConceptScore W2513521719C55493867 @default.
• W2513521719 hasConceptScore W2513521719C62231903 @default.
• W2513521719 hasConceptScore W2513521719C71924100 @default.
• W2513521719 hasConceptScore W2513521719C86803240 @default.
• W2513521719 hasIssue "7-8" @default.
• W2513521719 hasLocation W25135217191 @default.
• W2513521719 hasOpenAccess W2513521719 @default.
• W2513521719 hasPrimaryLocation W25135217191 @default.
• W2513521719 hasRelatedWork W1589208118 @default.
• W2513521719 hasRelatedWork W2040437316 @default.
• W2513521719 hasRelatedWork W2048548690 @default.
• W2513521719 hasRelatedWork W2069315162 @default.
• W2513521719 hasRelatedWork W2071032213 @default.
• W2513521719 hasRelatedWork W2110210351 @default.

• next