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- W2513550555 abstract "Background: here has been no prior systematic review of epidemiological aspects of all types of Parkinson-plus syndromes (PPS) in North African population. Objective: To determine the epidemiological aspects of PPS in a Tunisian monocentric cohort. Methods: A 12 years retrospective study, including all the patients diagnosed with PPS with parkinsonian syndrome (PS) (Dementia with Lewy bodies (DLB), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), multiple system atrophy (MSA), frontotemporal lobar degeneration with PS (FTLD-Park), PPS of undetermined origin (PPS-UO). Frequencies, age, sex, consanguinity rate, family and personal history were analyzed. Results: We included 210 patients with PPS (18.2% of all patients with PS followed in the department in the same period; DLB:53%, CBD: 15%, MSA: 9%, PSP:11%, FTLD-Park:4%,PPS-UO:8%). Sex-ratio: 1.3 (mainly males in DLB, CBDand PSP; mainly females in MSA, no sex differences in FTLD-Park). Mean age:73,5 years; mean age of onset: 66,9 years; mean age of onset of PS: 67 years[38-94]. Consanguinity rate was 33.3%. Family history of neurological pathologies was found in 60,4% (38.6 % with dementia, 18,6% with PS and 8.1% of similar cases). Conclusion: The frequency of PPS found in the present study was comparable to that reported for European population. DLB, the most common PPS in our series, has been recently included in epidemiological studies of Parkinsonism. Male predominance is established in PS. The high consanguinity rate in our series may explain the high percentage of similar cases. Further studies are needed to determine the suggested implication of genetic factors." @default.
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- W2513550555 date "2015-10-01" @default.
- W2513550555 modified "2023-10-14" @default.
- W2513550555 title "Parkinson-plus syndromes: epidemiological findings from a Tunisian cohort of 210 patients" @default.
- W2513550555 doi "https://doi.org/10.1016/j.jns.2015.08.941" @default.
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