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- W2513687983 abstract "11-Saxitoxinethanoic acid (SEA) is a member of the saxitoxin (STX) family of paralytic shellfish poisons, and contains an unusual C-C bond at the C11 position. Reported herein is a total synthesis of SEA. The key to our synthesis lies in a Mukaiyama aldol condensation reaction of silyl enol ether with glyoxylate in the presence of an anhydrous fluoride reagent, [Bu4 N][Ph3 SnF2 ], which directly constructs the crucial C-C bond at the C11 position in SEA. The NaV Ch-inhibitory activities of SEA and its derivatives were evaluated by means of cell-based assay. SEA showed an IC50 value of (47±12) nm, which is approximately twice as potent as decarbamoyl-STX (dcSTX)." @default.
- W2513687983 created "2016-09-16" @default.
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- W2513687983 date "2016-08-11" @default.
- W2513687983 modified "2023-10-10" @default.
- W2513687983 title "Total Synthesis of 11-Saxitoxinethanoic Acid and Evaluation of its Inhibitory Activity on Voltage-Gated Sodium Channels" @default.
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- W2513687983 doi "https://doi.org/10.1002/anie.201604155" @default.
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