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• W2513741145 abstract "Campylobacter jejuni is a Gram-negative bacterium and a foodborne pathogen that can cause mild to serious diseases in humans. C. jejuni is considered fastidious and lacks many classical stress response factors associated with other enteric pathogens. Yet C. jejuni successfully colonizes and persists in a wide range of niches, which prompted investigations into potential factors that might contribute to the pathobiology of this bacterium. Recently, the metabolism of inorganic polyphosphate (poly-P) and cognate enzymes, the polyphosphate kinases (PPKs) and the exopolyphosphatases (PPXs), has been implicated in C. jejuni's adaptation, resistance to stress, and cellular homeostasis. poly-P is a linear polymer of orthophosphate residues that serves as an energy source as well as a mediator of key cellular functions in many bacterial pathogens. This polymer is thought to have played a role in prebiotic evolution and is vital for a multitude of processes, including fidelity of DNA replication, survival, growth, motility, biofilm formation, quorum sensing, antibiotic resistance, invasion, and host colonization, among others. Here, the potential roles of poly-P metabolism and cognate enzymes in the pathobiology of C. jejuni are discussed. The relationship between poly-P metabolism and viable but nonculturable cell (VBNC) formation in C. jejuni is also highlighted. The latter is important because the inability to detect VBNCs using standard culture techniques may pose an underappreciated transmission route to consumers via contaminated foods. It is concluded that poly-P and associated enzymes contribute significantly to key survival and adaptation phenotypes in C. jejuni. Furthermore, the relationship between poly-P metabolism and VBNCs may represent an important breakthrough in the understanding of this enigmatic nonculturable state." @default.
• W2513741145 created "2016-09-16" @default.
• W2513741145 creator A5007063838 @default.
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• W2513741145 date "2016-08-12" @default.
• W2513741145 modified "2023-09-23" @default.
• W2513741145 title "Of a Tenacious and Versatile Relic: The Role of Inorganic Polyphosphate (Poly-P) Metabolism in the Survival, Adaptation, and Virulence ofCampylobacter Jejuni" @default.
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• W2513741145 doi "https://doi.org/10.1002/9781119004813.ch133" @default.
• W2513741145 hasPublicationYear "2016" @default.
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