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- W2513771435 abstract "HPV L1-based virus-like particles vaccines (VLPs) efficiently induce temporary prophylactic activity through the induction of neutralizing antibodies; however, VLPs that can provide prophylactic as well as therapeutic properties for longer periods of time are needed. For this purpose, we generated a novel HPV 16 L1-based chimeric virus-like particle (cVLP) produced in plants that contains a string of T-cell epitopes from HPV 16 E6 and E7 fused to its C-terminus. In the present study, we analyzed the per- sistence of specific IgG antibodies with neutralizing activity induced by immunization with these cVLPs, as well as their therapeutic potential in a tumor model of C57BL/6 mice. We observed that these cVLPs induced persistent IgG antibodies for over 12 months, with reac- tivity and neutralizing activity for VLPs composed of only the HPV-16 L1 protein. Efficient protection for long peri- ods of time and inhibition of tumor growth induced by TC- 1 tumor cells expressing HPV-16 E6/E7 oncoproteins, as well as significant tumor reduction (57 %), were observed in mice immunized with these cVLPs. Finally, we discuss the possibility that chimeric particles of the type described in this work may be the basis for developing HPV pro- phylactic and therapeutic vaccines with high efficacy." @default.
- W2513771435 created "2016-09-16" @default.
- W2513771435 creator A5079936146 @default.
- W2513771435 date "2014-01-01" @default.
- W2513771435 modified "2023-09-24" @default.
- W2513771435 title "Immunization with an HPV-16 L1-based chimeric virus-like particle containing HPV-16 E6 and E7 epitopes elicits long-lasting prophylactic and therapeutic efficacy in an HPV-16 tumor mice" @default.
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