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• W2513971531 abstract "There is limited information on the efficacy and safety of bronchial thermoplasty (BT) in real life . We evaluated the outcomes of the randomized clinical trials for BT in severe asthmatics, in whom the exclusion criteria were not strictly controlled. A case series of seven asthmatics (M/F: 4/3; age:<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mn fontstyle=italic>54.6</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle=italic>2.9</mml:mn></mml:math>years) is reported. Subjects had a statistically significant improvement in AQLQ (from a mean of<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mn fontstyle=italic>3.96</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle=italic>1.1</mml:mn></mml:math>to<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mn fontstyle=italic>4.5</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle=italic>1.2</mml:mn></mml:math>and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mn fontstyle=italic>5.5</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle=italic>0.6</mml:mn></mml:math>after 6 and 12 months of treatment;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.0007</mml:mn></mml:math>) and in the ACQ score (from<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mn fontstyle=italic>2.77</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle=italic>0.8</mml:mn></mml:math>to<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mn fontstyle=italic>1.83</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle=italic>1.2</mml:mn></mml:math>and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mn fontstyle=italic>1.5</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle=italic>0.8</mml:mn></mml:math>after 6 and 12 months;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M9><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle=italic>0.001</mml:mn></mml:math>). In the year after BT, severe exacerbations, salbutamol use, and OCS use were significantly lower compared with the 1-yr pretreatment period (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M10><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle=italic>0.001</mml:mn></mml:math>). No ED visits and hospitalization occurred in the year after BT. No changes in functional parameters were recorded. Our investigation confirms the safety and efficacy of BT in severe asthmatics in real life settings." @default.
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• W2513971531 date "2016-01-01" @default.
• W2513971531 modified "2023-09-26" @default.
• W2513971531 title "How Effective and Safe Is Bronchial Thermoplasty in “Real Life” Asthmatics Compared to Those Enrolled in Randomized Clinical Trials?" @default.
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• W2513971531 doi "https://doi.org/10.1155/2016/9132198" @default.
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