Matches in SemOpenAlex for { <https://semopenalex.org/work/W2514242523> ?p ?o ?g. }
- W2514242523 abstract "Acetyl amantadine (AcAm) is produced from amantadine (Am) in vivo upon catalysis by spermidine/spermine N 1 -acetyl transferase (SSAT). SSAT is a biomarker for multiple aggressive cancers, and the analysis of AcAm in urine has been promoted as a proxy measure for the early detection of cancer. We report here the development and optimization of cucurbit[7]uril–dye pair based indicator displacement assay (IDA) for the detection of AcAm in solution. In deionized water, using Rhodamine B as the dye, the limit of detection of AcAm was 0.087 μM with a linear response range from 0 to 1 μM. Using berberine as the dye, the limit of detection was 0.077 μM with the same range of linear response. Our efforts and difficulties in translating this assay to function in human urine are also described. We achieve a partial response of the berberine IDA to the presence of AcAm in urine that has undergone a simple PD-10 desalting step." @default.
- W2514242523 created "2016-09-16" @default.
- W2514242523 creator A5000432967 @default.
- W2514242523 creator A5002271677 @default.
- W2514242523 creator A5016735880 @default.
- W2514242523 creator A5019244159 @default.
- W2514242523 creator A5088926667 @default.
- W2514242523 date "2016-11-01" @default.
- W2514242523 modified "2023-09-22" @default.
- W2514242523 title "A supramolecular indicator displacement assay for acetyl amantadine, a proxy biomarker for spermidine/spermine N1-acetyltransferase (SSAT) activity" @default.
- W2514242523 cites W1820204933 @default.
- W2514242523 cites W1963835169 @default.
- W2514242523 cites W1969099293 @default.
- W2514242523 cites W1974620743 @default.
- W2514242523 cites W1987852123 @default.
- W2514242523 cites W2001686550 @default.
- W2514242523 cites W2001770449 @default.
- W2514242523 cites W2012496595 @default.
- W2514242523 cites W2012521191 @default.
- W2514242523 cites W2017108099 @default.
- W2514242523 cites W2017777108 @default.
- W2514242523 cites W2020451019 @default.
- W2514242523 cites W2021462887 @default.
- W2514242523 cites W2022532182 @default.
- W2514242523 cites W2032133327 @default.
- W2514242523 cites W2043672286 @default.
- W2514242523 cites W2057469006 @default.
- W2514242523 cites W2059874121 @default.
- W2514242523 cites W2063728523 @default.
- W2514242523 cites W2065320504 @default.
- W2514242523 cites W2075704126 @default.
- W2514242523 cites W2081560450 @default.
- W2514242523 cites W2083756382 @default.
- W2514242523 cites W2087171159 @default.
- W2514242523 cites W2088396668 @default.
- W2514242523 cites W2091068412 @default.
- W2514242523 cites W2091415139 @default.
- W2514242523 cites W2092459136 @default.
- W2514242523 cites W2100465118 @default.
- W2514242523 cites W2103388008 @default.
- W2514242523 cites W2103688411 @default.
- W2514242523 cites W2120682265 @default.
- W2514242523 cites W2126402783 @default.
- W2514242523 cites W2131074035 @default.
- W2514242523 cites W2134793522 @default.
- W2514242523 cites W2138217484 @default.
- W2514242523 cites W2138309609 @default.
- W2514242523 cites W2140181274 @default.
- W2514242523 cites W2142786818 @default.
- W2514242523 cites W2144927296 @default.
- W2514242523 cites W2151227837 @default.
- W2514242523 cites W2192072986 @default.
- W2514242523 cites W2266618839 @default.
- W2514242523 cites W2317136863 @default.
- W2514242523 cites W2318253638 @default.
- W2514242523 cites W2320229303 @default.
- W2514242523 cites W2320376660 @default.
- W2514242523 cites W2333059703 @default.
- W2514242523 cites W2498668031 @default.
- W2514242523 doi "https://doi.org/10.1139/cjc-2016-0411" @default.
- W2514242523 hasPublicationYear "2016" @default.
- W2514242523 type Work @default.
- W2514242523 sameAs 2514242523 @default.
- W2514242523 citedByCount "2" @default.
- W2514242523 countsByYear W25142425232017 @default.
- W2514242523 countsByYear W25142425232018 @default.
- W2514242523 crossrefType "journal-article" @default.
- W2514242523 hasAuthorship W2514242523A5000432967 @default.
- W2514242523 hasAuthorship W2514242523A5002271677 @default.
- W2514242523 hasAuthorship W2514242523A5016735880 @default.
- W2514242523 hasAuthorship W2514242523A5019244159 @default.
- W2514242523 hasAuthorship W2514242523A5088926667 @default.
- W2514242523 hasConcept C10349863 @default.
- W2514242523 hasConcept C119128265 @default.
- W2514242523 hasConcept C181199279 @default.
- W2514242523 hasConcept C185592680 @default.
- W2514242523 hasConcept C2776109719 @default.
- W2514242523 hasConcept C2777497464 @default.
- W2514242523 hasConcept C2780026642 @default.
- W2514242523 hasConcept C43617362 @default.
- W2514242523 hasConcept C55493867 @default.
- W2514242523 hasConcept C71924100 @default.
- W2514242523 hasConcept C98274493 @default.
- W2514242523 hasConceptScore W2514242523C10349863 @default.
- W2514242523 hasConceptScore W2514242523C119128265 @default.
- W2514242523 hasConceptScore W2514242523C181199279 @default.
- W2514242523 hasConceptScore W2514242523C185592680 @default.
- W2514242523 hasConceptScore W2514242523C2776109719 @default.
- W2514242523 hasConceptScore W2514242523C2777497464 @default.
- W2514242523 hasConceptScore W2514242523C2780026642 @default.
- W2514242523 hasConceptScore W2514242523C43617362 @default.
- W2514242523 hasConceptScore W2514242523C55493867 @default.
- W2514242523 hasConceptScore W2514242523C71924100 @default.
- W2514242523 hasConceptScore W2514242523C98274493 @default.
- W2514242523 hasLocation W25142425231 @default.
- W2514242523 hasOpenAccess W2514242523 @default.
- W2514242523 hasPrimaryLocation W25142425231 @default.
- W2514242523 hasRelatedWork W1967497325 @default.
- W2514242523 hasRelatedWork W2023970856 @default.
- W2514242523 hasRelatedWork W2865824112 @default.