FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2514291295> ?p ?o ?g. }

• W2514291295 endingPage "199" @default.
• W2514291295 startingPage "192" @default.
• W2514291295 abstract "ABSTRACT Background and objective Malignant pleural effusion ( MPE ) affects >90% of mesothelioma patients. Research on MPE has focused on its physical impact on breathlessness; MPE is rich in growth mediators but its contribution to tumour biology has not been investigated. We aimed to examine the potential effects of MPE in promoting growth, migration and chemo‐resistance of mesothelioma. Methods Pleural fluid samples from 151 patients (56 mesothelioma, 60 metastatic pleural cancer and 35 benign) were used. Seven validated human mesothelioma cell lines and three primary cultured mesothelioma lines were employed. Results Pleural fluid from mesothelioma patients (diluted to 30%) consistently stimulated cell proliferation (trypan‐blue cell viability assay) in five mesothelioma cell lines tested by (median) 2.23‐fold over controls (all P < 0.0001). The fluid also induced cell migration by (median) 2.13‐fold in six mesothelioma cell lines using scratch‐wound assay. In a murine flank model of mesothelioma, tumour infused with daily instillations of pleural fluid grew significantly faster over saline controls (median 52.5 cm 2 vs 28.0 cm 2 at day 13, P = 0.028). Addition of MPE (diluted to 30%) to culture media significantly protected mesothelioma from cisplatin/pemetrexed‐induced cell death in all three cell lines tested (median fold reduction of 1.29, 1.98 and 3.90, all P < 0.001 vs control). The growth effects of matched pleural fluid and cultured mesothelioma cells from the same patients did not differ significantly from unmatched pairs. Conclusion This ‘proof‐of‐concept’ study reveals potent biological capabilities of malignant pleural fluid in mesothelioma pathobiology." @default.
• W2514291295 created "2016-09-16" @default.
• W2514291295 creator A5005272265 @default.
• W2514291295 creator A5010390663 @default.
• W2514291295 creator A5051279706 @default.
• W2514291295 creator A5077793881 @default.
• W2514291295 creator A5085495966 @default.
• W2514291295 creator A5085581798 @default.
• W2514291295 creator A5087099593 @default.
• W2514291295 creator A5088590298 @default.
• W2514291295 date "2016-08-25" @default.
• W2514291295 modified "2023-10-01" @default.
• W2514291295 title "Malignant pleural fluid from mesothelioma has potent biological activities" @default.
• W2514291295 cites W1488288160 @default.
• W2514291295 cites W1971288719 @default.
• W2514291295 cites W1999626546 @default.
• W2514291295 cites W2022200777 @default.
• W2514291295 cites W2040333460 @default.
• W2514291295 cites W2097349684 @default.
• W2514291295 cites W2100592123 @default.
• W2514291295 cites W2102627969 @default.
• W2514291295 cites W2114910450 @default.
• W2514291295 cites W2126411666 @default.
• W2514291295 cites W2132834292 @default.
• W2514291295 cites W2136123812 @default.
• W2514291295 cites W2141178172 @default.
• W2514291295 cites W2159803213 @default.
• W2514291295 cites W2169486903 @default.
• W2514291295 cites W2215044613 @default.
• W2514291295 cites W65533086 @default.
• W2514291295 doi "https://doi.org/10.1111/resp.12874" @default.
• W2514291295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27560254" @default.
• W2514291295 hasPublicationYear "2016" @default.
• W2514291295 type Work @default.
• W2514291295 sameAs 2514291295 @default.
• W2514291295 citedByCount "26" @default.
• W2514291295 countsByYear W25142912952016 @default.
• W2514291295 countsByYear W25142912952017 @default.
• W2514291295 countsByYear W25142912952018 @default.
• W2514291295 countsByYear W25142912952019 @default.
• W2514291295 countsByYear W25142912952020 @default.
• W2514291295 countsByYear W25142912952021 @default.
• W2514291295 countsByYear W25142912952022 @default.
• W2514291295 countsByYear W25142912952023 @default.
• W2514291295 crossrefType "journal-article" @default.
• W2514291295 hasAuthorship W2514291295A5005272265 @default.
• W2514291295 hasAuthorship W2514291295A5010390663 @default.
• W2514291295 hasAuthorship W2514291295A5051279706 @default.
• W2514291295 hasAuthorship W2514291295A5077793881 @default.
• W2514291295 hasAuthorship W2514291295A5085495966 @default.
• W2514291295 hasAuthorship W2514291295A5085581798 @default.
• W2514291295 hasAuthorship W2514291295A5087099593 @default.
• W2514291295 hasAuthorship W2514291295A5088590298 @default.
• W2514291295 hasBestOaLocation W25142912951 @default.
• W2514291295 hasConcept C126322002 @default.
• W2514291295 hasConcept C142724271 @default.
• W2514291295 hasConcept C143998085 @default.
• W2514291295 hasConcept C2776178081 @default.
• W2514291295 hasConcept C2776517811 @default.
• W2514291295 hasConcept C2776694085 @default.
• W2514291295 hasConcept C2777240266 @default.
• W2514291295 hasConcept C2777407522 @default.
• W2514291295 hasConcept C2777714996 @default.
• W2514291295 hasConcept C2778239845 @default.
• W2514291295 hasConcept C2779634585 @default.
• W2514291295 hasConcept C502942594 @default.
• W2514291295 hasConcept C54355233 @default.
• W2514291295 hasConcept C71924100 @default.
• W2514291295 hasConcept C81885089 @default.
• W2514291295 hasConcept C86803240 @default.
• W2514291295 hasConceptScore W2514291295C126322002 @default.
• W2514291295 hasConceptScore W2514291295C142724271 @default.
• W2514291295 hasConceptScore W2514291295C143998085 @default.
• W2514291295 hasConceptScore W2514291295C2776178081 @default.
• W2514291295 hasConceptScore W2514291295C2776517811 @default.
• W2514291295 hasConceptScore W2514291295C2776694085 @default.
• W2514291295 hasConceptScore W2514291295C2777240266 @default.
• W2514291295 hasConceptScore W2514291295C2777407522 @default.
• W2514291295 hasConceptScore W2514291295C2777714996 @default.
• W2514291295 hasConceptScore W2514291295C2778239845 @default.
• W2514291295 hasConceptScore W2514291295C2779634585 @default.
• W2514291295 hasConceptScore W2514291295C502942594 @default.
• W2514291295 hasConceptScore W2514291295C54355233 @default.
• W2514291295 hasConceptScore W2514291295C71924100 @default.
• W2514291295 hasConceptScore W2514291295C81885089 @default.
• W2514291295 hasConceptScore W2514291295C86803240 @default.
• W2514291295 hasFunder F4320334705 @default.
• W2514291295 hasIssue "1" @default.
• W2514291295 hasLocation W25142912951 @default.
• W2514291295 hasOpenAccess W2514291295 @default.
• W2514291295 hasPrimaryLocation W25142912951 @default.
• W2514291295 hasRelatedWork W1991901410 @default.
• W2514291295 hasRelatedWork W2009040992 @default.
• W2514291295 hasRelatedWork W2083305999 @default.
• W2514291295 hasRelatedWork W2097943006 @default.
• W2514291295 hasRelatedWork W2132637325 @default.
• W2514291295 hasRelatedWork W2162580433 @default.
• W2514291295 hasRelatedWork W2417317824 @default.

• next