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- W2514561979 abstract "We present a case of an 81-year-old man with secondary autoimmune granulocytopenia in association with autoimmune thrombocytopenia. Treatment with granulocyte colony-stimulating factor (G-CSF) (5 mg/ kg/day s.c.) resulted in a rapid increase in the number of circulating granulocytes with a pronounced left shift. These changes were accompanied by up-regulation of the surface expression of FcgRI (CD64) and FcgRII (CD32) on the granulocytes. In addition, we noted a strong up-regulation of the FcgRIII (CD16) and the ac- tivation markers CD11b and CD66b on the granulo- cytes. The increase in the number of circulating granu- locytes was followed by a dramatic decrease in the level of cell-bound as well as circulating anti-granulocyte an- tibodies. It is hypothezised that the decrease in the lev- el of cell-bound as well as circulating anti-granulocyte antibodies may be the result of an increased adsorption of the antibodies by the granulocytes." @default.
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- W2514561979 date "1997-01-01" @default.
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- W2514561979 title "L. T. Vlasveld 7 M. de Haas 7 A. A. M. Ermens L. Porcelijn 7 J. A. van Marion-Kievit A. E. G. K. von dem Borne G-CSF-induced decrease of the anti-granulocyte autoantibody levels in a patient with autoimmune granulocytopenia" @default.
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