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• W2514570945 abstract "Neural cell adhesion molecule (NCAM), a membrane-associated glycoprotein and its polysialylated form (PSA-NCAM) play an important role in brain plasticity via regulating cell-cell interactions. Here, we demonstrate that the cytosolic serine protease prolyl endopeptidase (PREP) is able to regulate NCAM and PSA-NCAM. Using SH-SY5Y neuroblastoma cell line with stable overexpression of PREP we found a remarkable loss in PSA-NCAM and reduced levels of NCAM 180 kDa and NCAM 140 kDa protein species and a significant increase in the NCAM immunoreactive band migrating at an apparent molecular weight of 120 kDa in PREP-overexpressing cells. Moreover, increased levels of NCAM fragments in the concentrated medium derived from PREP-overexpressing cells were found. PREP overexpression selectively induced an activation of matrix metalloproteinase-9 (MMP-9), which could be involved in the observed degradation of NCAM, as MMP-9 neutralization reduced the levels of NCAM fragments in cell culture medium. We propose that increased PREP levels promote epidermal growth factor (EGF)-receptor signaling, which in turn activates MMP-9. In conclusion, our findings provide evidence for the novel roles for PREP in mechanisms regulating cellular plasticity via NCAM and PSA-NCAM." @default.
• W2514570945 created "2016-09-16" @default.
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• W2514570945 date "2016-01-01" @default.
• W2514570945 modified "2023-09-23" @default.
• W2514570945 title "Prolyl endopeptidase is involved in the degradation of neural cell adhesion molecules in vitro" @default.
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• W2514570945 cites W1591653197 @default.
• W2514570945 cites W1764151989 @default.
• W2514570945 cites W1814964070 @default.
• W2514570945 cites W1834582965 @default.
• W2514570945 cites W1901042123 @default.
• W2514570945 cites W1964027828 @default.
• W2514570945 cites W1964709514 @default.
• W2514570945 cites W1965735757 @default.
• W2514570945 cites W1967095650 @default.
• W2514570945 cites W1968723804 @default.
• W2514570945 cites W1969529880 @default.
• W2514570945 cites W1969765223 @default.
• W2514570945 cites W1970811058 @default.
• W2514570945 cites W1970878854 @default.
• W2514570945 cites W1971108781 @default.
• W2514570945 cites W1971767541 @default.
• W2514570945 cites W1974645020 @default.
• W2514570945 cites W1974665084 @default.
• W2514570945 cites W1975149550 @default.
• W2514570945 cites W1982704287 @default.
• W2514570945 cites W1983565759 @default.
• W2514570945 cites W1984243890 @default.
• W2514570945 cites W1985936398 @default.
• W2514570945 cites W1987875997 @default.
• W2514570945 cites W1989984498 @default.
• W2514570945 cites W1991771887 @default.
• W2514570945 cites W1992500134 @default.
• W2514570945 cites W1994863160 @default.
• W2514570945 cites W1999043545 @default.
• W2514570945 cites W2002689706 @default.
• W2514570945 cites W2010304520 @default.
• W2514570945 cites W2012933599 @default.
• W2514570945 cites W2016623538 @default.
• W2514570945 cites W2019986705 @default.
• W2514570945 cites W2020384537 @default.
• W2514570945 cites W2021200462 @default.
• W2514570945 cites W2021419918 @default.
• W2514570945 cites W2029587634 @default.
• W2514570945 cites W2030739471 @default.
• W2514570945 cites W2032009340 @default.
• W2514570945 cites W2033579041 @default.
• W2514570945 cites W2034019339 @default.
• W2514570945 cites W2037574006 @default.
• W2514570945 cites W2047121898 @default.
• W2514570945 cites W2048571357 @default.
• W2514570945 cites W2049054255 @default.
• W2514570945 cites W2050120618 @default.
• W2514570945 cites W2053247155 @default.
• W2514570945 cites W2054036316 @default.
• W2514570945 cites W2055573155 @default.
• W2514570945 cites W2060883955 @default.
• W2514570945 cites W2061842603 @default.
• W2514570945 cites W2062408667 @default.
• W2514570945 cites W2066739717 @default.
• W2514570945 cites W2067085539 @default.
• W2514570945 cites W2067495948 @default.
• W2514570945 cites W2077721229 @default.
• W2514570945 cites W2081030321 @default.
• W2514570945 cites W2085019946 @default.
• W2514570945 cites W2090872025 @default.
• W2514570945 cites W2095154551 @default.
• W2514570945 cites W2095917032 @default.
• W2514570945 cites W2102599317 @default.
• W2514570945 cites W2104720463 @default.
• W2514570945 cites W2106263560 @default.
• W2514570945 cites W2107801018 @default.
• W2514570945 cites W2109103923 @default.
• W2514570945 cites W2109955285 @default.
• W2514570945 cites W2112399469 @default.
• W2514570945 cites W2138706322 @default.
• W2514570945 cites W2143276862 @default.
• W2514570945 cites W2171960232 @default.
• W2514570945 cites W2222068782 @default.
• W2514570945 cites W2288087911 @default.
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• W2514570945 doi "https://doi.org/10.1242/jcs.181891" @default.
• W2514570945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27566163" @default.
• W2514570945 hasPublicationYear "2016" @default.
• W2514570945 type Work @default.
• W2514570945 sameAs 2514570945 @default.

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