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- W2514846441 abstract "Several N,N'-bis(n-alkyl-4,13-diaza[18]crown-6) lariat ethers were found to significantly enhance the potency of rifampicin and tetracycline, but not erythromycin and kanamycin, against the non-pathogenic DH5α and K-12 strains of Escherichia coli when administered at levels below their minimum inhibitory concentrations (MICs). The enhancements in antibiotic potency observed for the lariat ethers ranged from three- to 20-fold, depending on the strain of E. coli, the antibiotic, and the lengths of the alkyl chains attached at the macroring nitrogen atoms. The dialkyl lariat ethers, previously thought to only be cation carriers, formed well-behaved, ion-conducting pores in soybean asolectin membranes, as judged by planar bilayer conductance measurements. The ability of lariat ethers to form stable pores, which appeared to be aggregated, depended in part on alkyl chain length and in part on the composition of the bilayer membrane in which they were studied." @default.
- W2514846441 created "2016-09-16" @default.
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- W2514846441 date "2016-10-20" @default.
- W2514846441 modified "2023-10-13" @default.
- W2514846441 title "Antibiotic Potency against<i>E. coli</i>Is Enhanced by Channel-Forming Alkyl Lariat Ethers" @default.
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- W2514846441 doi "https://doi.org/10.1002/cbic.201600428" @default.
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