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- W2514920385 abstract "Directed evolution has emerged as a protein engineering method that often eliminates the limitations assumed to be prohibitive for the application of enzymes. This chapter summarizes the evolution, strategy, and scale-up of a Baeyer-Villiger monooxygenase (BVMO) for the production of esomeprazole and a monoamine oxidase (MAO) for the production of boceprevir and compares with the chemosynthetic routes. It discusses the evolution and scale-up of MAO and the emerging technologies that are the result of a continuing collaboration between Codexis, Inc. and Merck & Co., Inc. The chapter explores advancements and challenges remaining for the application of alternate monooxygenases. The potential utility of cytochrome P450s (CYPs) and styrene monoxygenases (SMOs) as biocatalysts for industrial-scale syntheses has long been recognized due to their ability to catalyze regio- and stereoselective hydroxylations of nonactivated C-H bonds and epoxidations of olefins using molecular oxygen as the oxidant." @default.
- W2514920385 created "2016-09-16" @default.
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- W2514920385 date "2016-08-17" @default.
- W2514920385 modified "2023-10-17" @default.
- W2514920385 title "Enzyme Catalysis: Exploiting Biocatalysis and Aerobic Oxidations for High-Volume and High-Value Pharmaceutical Syntheses" @default.
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- W2514920385 doi "https://doi.org/10.1002/9783527690121.ch18" @default.
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