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- W2515087232 abstract "A full understanding of the pharmacokinetic (PK) behavior of each anti-TB drug and drug combinations is essential to determine the optimum dose/dosing regimen for a specific patient population. This information is also required to establish pharmacokinetic– pharmacodynamic (PK–PD) profile to evaluate their efficacy in TB treatment and to reduce the emergence of drug-resistant strains. In order to fully characterize the PK behavior of a drug, it is necessary to know its physicochemical properties, the best formulation and route of administration to enhance its therapeutic potential and to select the most suitable animal model. The biopharmaceutical and PK properties of each drug will determine the drug-distribution and -elimination mechanisms after administration and its concentration at the target tissue. These factors will determine the success of therapy in decreasing bacterial burden. This chapter focuses on the preclinical pharmacokinetics of anti-TB drugs and provides comparative case studies of selected anti-TB drugs." @default.
- W2515087232 created "2016-09-16" @default.
- W2515087232 creator A5042395268 @default.
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- W2515087232 date "2016-08-26" @default.
- W2515087232 modified "2023-10-18" @default.
- W2515087232 title "Preclinical Pharmacokinetics of Antitubercular Drugs" @default.
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- W2515087232 doi "https://doi.org/10.1002/9781118943182.ch7" @default.
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