FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2515147030> ?p ?o ?g. }

• W2515147030 endingPage "60534" @default.
• W2515147030 startingPage "60519" @default.
• W2515147030 abstract "// Cong Zhang 1, * , Zuohan Peng 1, * , Minglu Zhu 1 , Penglong Wang 1 , Xiao Du 1 , Xiang Li 1 , Yu Liu 1 , Yan Jin 1 , Michael A. McNutt 1 , Yuxin Yin 1 1 Institute of Systems Biomedicine, State Key Laboratory of Natural and Biomimetic Drugs, Beijing Key Laboratory of Tumor Systems Biology, Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, Peking-Tsinghua Center for Life Sciences, Beijing, 100191, China * These authors have contributed equally to this work Correspondence to: Yuxin Yin, email: yinyuxin@hsc.pku.edu.cn Keywords: USP9X, pVHL, mutation, protein stability, proliferation Received: January 06, 2016     Accepted: July 26, 2016     Published: August 09, 2016 ABSTRACT Numerous mutations of the Von Hippel-Lindau ( VHL ) gene have been reported to cause dysfunction of VHL protein (pVHL) and lead to processes related to tumor progression. pVHL acts as an E3 ligase and degrades downstream targets, such as hypoxia-inducible transcription factor (HIF) which is essential for tumor growth. Previous studies reported reduction of VHL protein, rather than mRNA in VHL-related tumor patients, suggesting that instability of the pVHL protein itself is a primary cause of dysfunction. Regulation of pVHL stability has therefore been a major focus of research. We report that ubiquitin-specific protease 9X (USP9X), which is a deubiquitinase binds and promotes degradation of both wild-type and mutants of pVHL that retain E3 ligase function, thus activating the HIF pathway. USP9X degrades pVHL through protection of its substrate, the newly identified pVHL E3 ligase Smurf1. In addition, USP9X activates glycolysis and promotes cell proliferation through pVHL. Treatment with a USP9X inhibitor shows an effect similar to USP9X knockdown in pVHL induction, and suppresses HIF activity. Our findings demonstrate that USP9X is a novel regulator of pVHL stability, and USP9X may be a therapeutic target for treatment of VHL-related tumors." @default.
• W2515147030 created "2016-09-16" @default.
• W2515147030 creator A5010295861 @default.
• W2515147030 creator A5043931578 @default.
• W2515147030 creator A5056621420 @default.
• W2515147030 creator A5057416689 @default.
• W2515147030 creator A5060284538 @default.
• W2515147030 creator A5065214501 @default.
• W2515147030 creator A5065487957 @default.
• W2515147030 creator A5074734978 @default.
• W2515147030 creator A5078128904 @default.
• W2515147030 creator A5086894930 @default.
• W2515147030 date "2016-08-09" @default.
• W2515147030 modified "2023-10-18" @default.
• W2515147030 title "USP9X destabilizes pVHL and promotes cell proliferation" @default.
• W2515147030 cites W117573336 @default.
• W2515147030 cites W1749022239 @default.
• W2515147030 cites W1824015767 @default.
• W2515147030 cites W1888266266 @default.
• W2515147030 cites W1963533810 @default.
• W2515147030 cites W1966051760 @default.
• W2515147030 cites W1967408167 @default.
• W2515147030 cites W1968425609 @default.
• W2515147030 cites W1968445925 @default.
• W2515147030 cites W1968994392 @default.
• W2515147030 cites W1969341640 @default.
• W2515147030 cites W1973092951 @default.
• W2515147030 cites W1976955696 @default.
• W2515147030 cites W1978173977 @default.
• W2515147030 cites W1982491440 @default.
• W2515147030 cites W1986464453 @default.
• W2515147030 cites W1988935612 @default.
• W2515147030 cites W1990607537 @default.
• W2515147030 cites W1991249033 @default.
• W2515147030 cites W1993614837 @default.
• W2515147030 cites W1994691942 @default.
• W2515147030 cites W2006792487 @default.
• W2515147030 cites W2011562442 @default.
• W2515147030 cites W2013883770 @default.
• W2515147030 cites W2020511385 @default.
• W2515147030 cites W2023952710 @default.
• W2515147030 cites W2025000517 @default.
• W2515147030 cites W2027606367 @default.
• W2515147030 cites W2031485253 @default.
• W2515147030 cites W2039841560 @default.
• W2515147030 cites W2042620086 @default.
• W2515147030 cites W2045640538 @default.
• W2515147030 cites W2050140657 @default.
• W2515147030 cites W2050745715 @default.
• W2515147030 cites W2054827417 @default.
• W2515147030 cites W2054987125 @default.
• W2515147030 cites W2060778832 @default.
• W2515147030 cites W2068555261 @default.
• W2515147030 cites W2068919366 @default.
• W2515147030 cites W2074459286 @default.
• W2515147030 cites W2079251282 @default.
• W2515147030 cites W2085377666 @default.
• W2515147030 cites W2087841059 @default.
• W2515147030 cites W2091752123 @default.
• W2515147030 cites W2096618803 @default.
• W2515147030 cites W2108366666 @default.
• W2515147030 cites W2108426942 @default.
• W2515147030 cites W2110272715 @default.
• W2515147030 cites W2111608545 @default.
• W2515147030 cites W2118423420 @default.
• W2515147030 cites W2122438377 @default.
• W2515147030 cites W2123339548 @default.
• W2515147030 cites W2130219349 @default.
• W2515147030 cites W2130272846 @default.
• W2515147030 cites W2131717611 @default.
• W2515147030 cites W2133810023 @default.
• W2515147030 cites W2134960373 @default.
• W2515147030 cites W2144625075 @default.
• W2515147030 cites W2145424370 @default.
• W2515147030 cites W2146933781 @default.
• W2515147030 cites W2147268550 @default.
• W2515147030 cites W2148270074 @default.
• W2515147030 cites W2149020418 @default.
• W2515147030 cites W2149441684 @default.
• W2515147030 cites W2155643508 @default.
• W2515147030 cites W2157641713 @default.
• W2515147030 cites W2161874576 @default.
• W2515147030 cites W2165865627 @default.
• W2515147030 cites W2167687415 @default.
• W2515147030 cites W2172170481 @default.
• W2515147030 cites W2325219633 @default.
• W2515147030 cites W2596045242 @default.
• W2515147030 cites W4285719527 @default.
• W2515147030 doi "https://doi.org/10.18632/oncotarget.11139" @default.
• W2515147030 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5312400" @default.
• W2515147030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27517496" @default.
• W2515147030 hasPublicationYear "2016" @default.
• W2515147030 type Work @default.
• W2515147030 sameAs 2515147030 @default.
• W2515147030 citedByCount "20" @default.
• W2515147030 countsByYear W25151470302017 @default.
• W2515147030 countsByYear W25151470302018 @default.
• W2515147030 countsByYear W25151470302019 @default.

• next