FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2515278375> ?p ?o ?g. }

• W2515278375 endingPage "86" @default.
• W2515278375 startingPage "75" @default.
• W2515278375 abstract "Irinotecan (IRT) is an important part of the first- and second-line regimen for metastatic colorectal and some other cancers. However, IRT suffers the constraints of pH-dependent conversion of active lactone form to inactive carboxylate form, burst release owing to its aqueous solubility, short half-life and dose-dependent side effects. In this study, we developed polymeric nanoparticles (NPs) that not only deliver IRT to tumor sites, but also overcome its drawbacks by preserving active lactone conformation, prolonging the plasma circulation time, and by providing sustained release. IRT complex was rendered hydrophobic by ion-pairing with anions (docusate sodium, sodium lauryl sulfate, and sodium tripolyphosphate), and loaded in PEG-PLGA NPs via water/oil/water double emulsification method. The NPs were spherical, ∼60nm, monodispersed, and had shell-core morphology. They retained >80% lactone form for more than 1 month of storage and exhibited sustained release characteristics. In addition, sub -100nm size of NPs offered elevated cellular internalization. Owing to the presence of hydrophilic PEG outer layer and drug-loaded hydrophobic PLGA core, NPs conferred excellent plasma stability and prolonged the retention time of IRT by more than 10-fold as compared to free IRT. Therefore, this system could provide an excellent platform for efficient and sustained delivery of IRT and similar labile drugs to the tumor site, while maintaining their chemical integrity." @default.
• W2515278375 created "2016-09-16" @default.
• W2515278375 creator A5034418015 @default.
• W2515278375 creator A5037464191 @default.
• W2515278375 creator A5048381976 @default.
• W2515278375 creator A5066449360 @default.
• W2515278375 creator A5067410151 @default.
• W2515278375 creator A5083751923 @default.
• W2515278375 creator A5086090575 @default.
• W2515278375 creator A5090451913 @default.
• W2515278375 date "2016-10-01" @default.
• W2515278375 modified "2023-09-23" @default.
• W2515278375 title "Development of polymeric irinotecan nanoparticles using a novel lactone preservation strategy" @default.
• W2515278375 cites W1968232376 @default.
• W2515278375 cites W1971656004 @default.
• W2515278375 cites W1974822561 @default.
• W2515278375 cites W1986294502 @default.
• W2515278375 cites W2009737103 @default.
• W2515278375 cites W2018557806 @default.
• W2515278375 cites W2024873626 @default.
• W2515278375 cites W2032263279 @default.
• W2515278375 cites W2039049126 @default.
• W2515278375 cites W2045266036 @default.
• W2515278375 cites W2058740020 @default.
• W2515278375 cites W2061389108 @default.
• W2515278375 cites W2075488756 @default.
• W2515278375 cites W2087093435 @default.
• W2515278375 cites W2117954070 @default.
• W2515278375 cites W2146274229 @default.
• W2515278375 cites W2156980852 @default.
• W2515278375 cites W2163409320 @default.
• W2515278375 doi "https://doi.org/10.1016/j.ijpharm.2016.08.018" @default.
• W2515278375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27558884" @default.
• W2515278375 hasPublicationYear "2016" @default.
• W2515278375 type Work @default.
• W2515278375 sameAs 2515278375 @default.
• W2515278375 citedByCount "31" @default.
• W2515278375 countsByYear W25152783752017 @default.
• W2515278375 countsByYear W25152783752018 @default.
• W2515278375 countsByYear W25152783752019 @default.
• W2515278375 countsByYear W25152783752020 @default.
• W2515278375 countsByYear W25152783752021 @default.
• W2515278375 countsByYear W25152783752022 @default.
• W2515278375 countsByYear W25152783752023 @default.
• W2515278375 crossrefType "journal-article" @default.
• W2515278375 hasAuthorship W2515278375A5034418015 @default.
• W2515278375 hasAuthorship W2515278375A5037464191 @default.
• W2515278375 hasAuthorship W2515278375A5048381976 @default.
• W2515278375 hasAuthorship W2515278375A5066449360 @default.
• W2515278375 hasAuthorship W2515278375A5067410151 @default.
• W2515278375 hasAuthorship W2515278375A5083751923 @default.
• W2515278375 hasAuthorship W2515278375A5086090575 @default.
• W2515278375 hasAuthorship W2515278375A5090451913 @default.
• W2515278375 hasConcept C10138342 @default.
• W2515278375 hasConcept C108215921 @default.
• W2515278375 hasConcept C121608353 @default.
• W2515278375 hasConcept C126322002 @default.
• W2515278375 hasConcept C155574463 @default.
• W2515278375 hasConcept C155672457 @default.
• W2515278375 hasConcept C162324750 @default.
• W2515278375 hasConcept C171250308 @default.
• W2515278375 hasConcept C178790620 @default.
• W2515278375 hasConcept C184651966 @default.
• W2515278375 hasConcept C185592680 @default.
• W2515278375 hasConcept C192562407 @default.
• W2515278375 hasConcept C21951064 @default.
• W2515278375 hasConcept C2776612806 @default.
• W2515278375 hasConcept C2778074193 @default.
• W2515278375 hasConcept C2779682216 @default.
• W2515278375 hasConcept C2779820397 @default.
• W2515278375 hasConcept C2780259306 @default.
• W2515278375 hasConcept C526805850 @default.
• W2515278375 hasConcept C537181965 @default.
• W2515278375 hasConcept C54400483 @default.
• W2515278375 hasConcept C55493867 @default.
• W2515278375 hasConcept C71240020 @default.
• W2515278375 hasConcept C71924100 @default.
• W2515278375 hasConceptScore W2515278375C10138342 @default.
• W2515278375 hasConceptScore W2515278375C108215921 @default.
• W2515278375 hasConceptScore W2515278375C121608353 @default.
• W2515278375 hasConceptScore W2515278375C126322002 @default.
• W2515278375 hasConceptScore W2515278375C155574463 @default.
• W2515278375 hasConceptScore W2515278375C155672457 @default.
• W2515278375 hasConceptScore W2515278375C162324750 @default.
• W2515278375 hasConceptScore W2515278375C171250308 @default.
• W2515278375 hasConceptScore W2515278375C178790620 @default.
• W2515278375 hasConceptScore W2515278375C184651966 @default.
• W2515278375 hasConceptScore W2515278375C185592680 @default.
• W2515278375 hasConceptScore W2515278375C192562407 @default.
• W2515278375 hasConceptScore W2515278375C21951064 @default.
• W2515278375 hasConceptScore W2515278375C2776612806 @default.
• W2515278375 hasConceptScore W2515278375C2778074193 @default.
• W2515278375 hasConceptScore W2515278375C2779682216 @default.
• W2515278375 hasConceptScore W2515278375C2779820397 @default.
• W2515278375 hasConceptScore W2515278375C2780259306 @default.
• W2515278375 hasConceptScore W2515278375C526805850 @default.
• W2515278375 hasConceptScore W2515278375C537181965 @default.
• W2515278375 hasConceptScore W2515278375C54400483 @default.

• next